Related to receptor tyrosine kinase

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

RYK
Identifiers
AliasesRYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase, receptor like tyrosine kinase
External IDsOMIM: 600524; MGI: 101766; HomoloGene: 68287; GeneCards: RYK; OMA:RYK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005861
NM_002958

NM_001042607
NM_013649
NM_001284258

RefSeq (protein)

NP_001005861
NP_002949

NP_001036072
NP_001271187
NP_038677

Location (UCSC)Chr 3: 134.07 – 134.25 MbChr 9: 102.71 – 102.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.[5]

History

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The gene encoding mouse RYK was first identified in 1992.[6] Subsequently, cDNA encoding the RYK protein have been isolated from the following species.[7]

Structure

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In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[7]

Function

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RYK is involved in regulation of axon growth during development of the nervous system.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163785Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032547Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "RYK receptor like tyrosine kinase [ Homo sapiens (human) ]". National Center for Biotechnology Information, U.S. National Library of Medicine. 13 March 2020. Retrieved 2 April 2020.
  6. ^ Hovens CM, Stacker SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. Bibcode:1992PNAS...8911818H. doi:10.1073/pnas.89.24.11818. PMC 50648. PMID 1334548.
  7. ^ a b Halford MM, Stacker SA (2001). "Revelations of the RYK receptor". BioEssays. 23 (1): 34–45. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307. S2CID 18535933.
  8. ^ Hollis ER, Ishiko N, Yu T, Lu CC, Haimovich A, Tolentino K, Richman A, Tury A, Wang SH, Pessian M, Jo E, Kolodkin A, Zou Y (2016). "Ryk controls remapping of motor cortex during functional recovery after spinal cord injury". Nature Neuroscience. 19 (5): 697–705. doi:10.1038/nn.4282. PMC 4847956. PMID 27065364.

Further reading

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