Parathyroid hormone receptor

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]

parathyroid hormone 1 receptor
Identifiers
SymbolPTH1R
Alt. symbolsPTHR, PFE
NCBI gene5745
HGNC9608
OMIM168468
RefSeqNM_000316
UniProtQ03431
Other data
LocusChr. 3 p22-p21.1
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StructuresSwiss-model
DomainsInterPro
parathyroid hormone 2 receptor
Identifiers
SymbolPTH2R
NCBI gene5746
HGNC9609
OMIM601469
RefSeqNM_005048
UniProtP49190
Other data
LocusChr. 2 q33
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StructuresSwiss-model
DomainsInterPro

References

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  1. ^ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
  2. ^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. doi:10.1152/ajprenal.1999.277.5.F665. PMID 10564229. Archived from the original on 2009-02-13. Retrieved 2007-11-01.
  3. ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/mend.10.5.8732687. PMID 8732687.
  4. ^ Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.
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