# Homeostasis

Not to be confused with hemostasis.

Homeostasis or homoeostasis is the property of a system in which a variable (for example, the concentration of a substance in solution, or its temperature) is actively regulated to remain very nearly constant. This regulation occurs inside a defined environment (mostly within a living organism's body).[1] Examples of homeostasis include the regulation of the body temperature of an animal, the pH of its extracellular fluids, or the concentrations of sodium (Na+) and calcium (Ca2+) ions or of glucose in the blood plasma, despite changes in the animal’s environment, or what it has eaten, or what it is doing (for example, resting or exercising). Each of these variables is controlled by a separate “homeostat” (or regulator), which, together, maintain life. Homeostats are energy-consuming physiological mechanisms.[2]

The concept was described by French physiologist Claude Bernard in 1865 and the word was coined by Walter Bradford Cannon in 1926.[2][3]

Although the term was originally used to refer to processes within living organisms, it is frequently applied to technological control systems such as thermostats. A homeostat has an absolute requirement for a sensor to detect changes in the controlled entity's value, as well as an effector mechanism that reverses any detected deviation from the desired value (or “setpoint”) of the regulated entity. Since the correction of any error detected by the sensor is always in the opposite direction to the error, a homeostat relies on what is known as a negative feedback connection between the sensor and effector.[4][5] The effector's corrective effects are monitored by the sensor, which turns the corrective measures off when setpoint conditions have been restored.[6] Negative feedback systems are therefore referred to as "closed loop", or "negative feedback loops", to distinguish them from "open loop" systems where a stimulus (acting on a sensor) results in an, often, all-or-none response that is not subject to modification once it has been set in motion.[4][7][8]

## BiologicalEdit

The metabolic processes of all living organisms can only take place in very specific physical and chemical environments. The conditions vary with each organism, and with whether the chemical processes take place inside the cell or in the fluids bathing the cells in multicellular creatures. The best known homeostats in human and other mammalian bodies are regulators that keep the composition of the extracellular fluids (or the ”internal environment”) constant, especially with regard to the temperature, pH, osmolality, and the concentrations of Na+, K+, Ca2+, glucose and CO2 and O2. However, a great many other homeostats, encompassing many aspects of human physiology, control other entities in the body.

Circadian variation in body temperature, ranging from about 37.5 °C from 10 a.m. to 6 p.m., and falling to about 36.4 °C from 2 a.m. to 6 a.m.

An example of a basal body temperature chart in an adult woman. Day 1 is the first day after the last menstrual period. The rise in temperature between days 14 and 18 is indicative of ovulation. Temperature was taken orally with a regular fever thermometer. Temperature reading is very sensitive to breaks in the regular sleep-rhythm (e.g. "sleeping in" on day 25 ).

If an entity is homeostatically controlled it does not imply that its value is necessarily absolutely steady in health. Core body temperature is, for instance, regulated by a homeostat with temperature sensors in, amongst others, the hypothalamus of the brain.[9] However the set point of the regulator is regularly reset. For instance, core body temperature in humans varies during the course of the day (i.e. has a circadian rhythm), with the lowest temperatures occurring at night, and the highest in the afternoons (see diagram on the right). The temperature regulator's set point is also readjusted in adult women at the start of the luteal phase of the menstrual cycle (see the diagram on the right, below).[10][11] The temperature regulator's set point is also reset during infections to produce a fever.[9][12][13]

Homeostasis doesn't govern every activity in the body.[14][15] For instance the signal (be it via neurons or hormones) from the sensor to the effector is, of necessity, highly variable in order to convey information about the direction and magnitude of the error detected by the sensor.[16][17][18] Similarly the effector’s response needs to be highly adjustable to reverse the error – in fact it should be very nearly in proportion (but in the opposite direction) to the error that is threatening the internal environment.[7][8] For instance, the arterial blood pressure in mammals is homeostatically controlled, and measured by sensors in the aorta and carotid arteries. The sensors send messages via sensory nerves to the medulla oblongata of the brain indicating whether the blood pressure has fallen or risen, and by how much. The medulla oblongata then distributes messages along motor or efferent nerves belonging to the autonomic nervous system to a wide variety of effector organs, whose activity is consequently changed to reverse the error in the blood pressure. One of the effector organs is the heart whose rate is stimulated to rise (tachycardia) when the arterial blood pressure falls, or to slow down (bradycardia) when the pressure rises above set point. Thus the heart rate (for which there is no sensor in the body) is not homeostatically controlled, but is one of effector responses to errors in the arterial blood pressure. Another example is the rate of sweating. This is one of the effectors in the homeostatic control of body temperature, and therefore highly variable in rough proportion to the heat load that threatens to destabilize the body’s core temperature, for which there is a sensor in the hypothalamus of the brain.

Apart from the entities that are homeostatically controlled in the internal environment of the body, and the mechanisms that are responsible for this regulation, there are variables that are neither homeostatically controlled nor involved in the operation of homeostats. The blood urea concentration is an example. Mammals do not have “urea sensors”. Instead the concentration of urea is determined by a dynamic equilibrium, in much the same way that the water level in a river at any particular point along its course is determined. The level of a river is simply dependent on the rate at which water flows into a particular section and how fast it flows away from there. It therefore varies with the rainfall in the catchment area and obstructions or otherwise to the flow down stream – there is no energy consuming “regulation”. The blood urea concentration is comparable to the water level in a natural river. It is manufactured by the liver from the amino groups of the amino acids of proteins that are being degraded in this organ. It is then excreted by the kidneys which simply pass most of the urea in the glomerular filtrate on into the urine without active resorption or excretion by the renal tubules (a relatively small proportion of the urea in the tubules diffuses passively back into the blood as its concentration in the tubules rises when water, without urea, is removed from the tubular fluid). A high protein diet therefore produces high blood urea concentrations, and a protein-poor diet produced low blood plasma urea concentrations, without any physiological attempt to correct or mitigate these fluctuations in the level of urea in the extracellular fluids.

## Examples of some of the better understood physiological homeostatsEdit

### The core body temperature homeostatEdit

The counter-current flow of blood into a limb in a cold environment. On the left a cartoon of the blood flow into the flipper of a seal in icy water. The arterial blood is in close proximity to, indeed surrounded by, veins carrying cold blood back to the torso from the flipper which is almost at the same temperature as the icy water. The arterial blood is cooled by this counter-current flow of cold venous blood and arrives in the flipper at only a few degrees above the environmental temperature. As the blood returns in the veins it is warmed by the arterial blood, and arrives back in the torso at almost core temperature. Effectively the body heat has been short-circuited and does not enter the ice-cold flipper. The diagram on the right shows, in slightly more realistic form, the arrangement of the deep veins around the arteries in the limbs of mammals, all of whom can make use of the same mechanism as the seal to prevent heat loss from the body in cold weather.

Mammals regulate their core temperatures, using hypothalamic temperature sensors in their brains, but also elsewhere in their bodies. When core body temperature falls behavioral changes are set in motion, which, in humans, include the donning of warmer clothes, the seeking out of wind-free, warmer environments, and, eventually, the curling up in the “fetal position” to reduce the surface area (skin) exposed to the cold.[19]

The blood flow to the limbs is reduced to a minimum via sympathetic nerves which constrict the limb arteries. The blood returns from the limb through the deep veins which surround the artery like a coarsely knitted stocking. These deep veins are called venae comitantes (see diagram on the right).[20] This counter-current flow of blood into and out of a cold limb ensures that the arterial blood is cooled on its way into the limb, and is then re-warmed before it returns to the torso. The body heat is thus short-circuited before entering the inevitably cold limb, and relatively little heat is lost by the blood flow into that limb. The superficial subcutaneous veins of the limbs (which are very prominently visible in warm weather) are tightly constricted, as is the capillary blood flow to the skin in general, thus separating the blood as far as possible from the cold surroundings.

The metabolic rate is increased, initially by non-shivering thermogenesis,[21] followed by shivering thermogenesis if the earlier reactions are insufficient to correct the hypothermia.

When body temperature rises, or skin heat sensors detect a threatening rise in body temperature, behavioral changes cause the animal to seek shade, and, in humans, the sweat glands in the skin are stimulated via cholinergic sympathetic nerves to secrete a dilute watery fluid called sweat onto the skin, which, when it evaporates, cools the skin and the blood flowing through it. Panting is an alternative effector in many vertebrates, which cools the body also by the evaporation of water, but this time from the mucous membranes of the throat and mouth.

### The blood glucose homeostatEdit

All animals regulate the glucose concentration in their extracellular fluids.[22] In mammals the primary sensor is situated in the beta cells of the pancreatic islets.[23][24] The beta cells respond to a rise in the blood sugar level by secreting insulin into the blood, and simultaneously inhibiting their neighboring alpha cells from secreting glucagon into the blood.[23] This combination (high blood insulin levels and low glucagon levels) act on effector tissues, chief of which are the liver, fat cells and muscle cells. The liver is inhibited from producing glucose, taking it up instead, and converting it to glycogen and triglycerides. The glycogen is stored in the liver, but the triglycerides are secreted into the blood as very low-density lipoprotein (VLDL) particles which are taken up by adipose tissue, there to be stored as fats. The fat cells take up glucose through special glucose transporters (GLUT4), whose numbers in the cell wall are increased as a direct effect of insulin acting on these cells. The glucose that enters the fat cells in this manner is converted into triglycerides (via the same metabolic pathways as are used by the liver) and then stored in those fat cells together with the VLDL-derived triglycerides that were made in the liver. Muscle cells also take glucose up through insulin-sensitive GLUT4 glucose channels, and convert it into muscle glycogen.

When the beta cells in the pancreatic islets detect lower than normal blood glucose levels, insulin secretion into the blood ceases and the alpha cells are stimulated to secrete glucagon into the blood. This inhibits the uptake of glucose from the blood by the liver, fats cells and muscle. Instead the liver is strongly stimulated to manufacture glucose from glycogen (through glycogenolysis) and from non-carbohydrate sources (such as lactate and de-aminated amino acids) using a process known as gluconeogenesis. The glucose thus produced is discharged into the blood correcting the detected error (hypoglycemia). The glycogen stored in muscles remains in the muscles, and is only broken down, during exercise, to glucose-6-phosphate and thence to pyruvate to be fed into the citric acid cycle or turned into lactate. It is only the lactate and the waste products of the citric acid cycle that are returned to the blood. The liver can take up only the lactate, and by the process of energy consuming gluconeogenesis convert it back to glucose.

### The plasma ionized calcium homeostatEdit

The plasma ionized calcium (Ca2+) concentration is very tightly controlled by a pair of homeostats.[25] The sensor for the one is situated in the parathyroid glands, where the chief cells sense the Ca2+ level by means of specialized calcium receptors in their membranes. The sensors for the second homeostat are the parafollicular cells in the thyroid gland. The parathyroid chief cells secrete parathyroid hormone (PTH) in response to a fall in the plasma ionized calcium level; the parafollicular cells of the thyroid gland secrete calcitonin in response to a rise in the plasma ionized calcium level.

The effector organs of the first homeostat are the skeleton, the kidney, and, via a hormone released into the blood by the kidney in response to high PTH levels in the blood, the duodenum and jejunum. Parathyroid hormone (in high concentrations in the blood) causes bone resorption, releasing calcium into the plasma. This is a very rapid action which can correct a threatening hypocalcemia within minutes. High PTH concentrations cause the excretion of phosphate ions via the urine. Since phosphates combine with calcium ions to form insoluble salts, a decrease in the level of phosphates in the blood, releases free calcium ions into the plasma ionized calcium pool. PTH has a second action on the kidneys. It stimulates the manufacture and release, by the kidneys, of calcitriol (or 1,25 dihydroxycholecalciferol, or 1,25 dihydroxyvitamin D3) into the blood. This steroid hormone acts on the epithelial cells of the upper small intestine, increasing their capacity to absorb calcium from the gut contents into the blood.[26]

The second homeostat, with its sensors in the thyroid gland, releases calcitonin into the blood when the blood ionized calcium rises. This hormone acts primarily on bone, causing the rapid removal of calcium from the blood and depositing it, in insoluble form, in the skeleton.

The two homeostats working through PTH on the one hand, and calcitonin on the other, can very rapidly correct any impending error in the plasma ionized calcium level by either removing calcium from the blood and depositing it in the skeleton, or by removing calcium from it. The skeleton acts as an extremely large calcium store (about 1 kg) compared with the plasma calcium store (about 180 mg). Longer term regulation occurs through calcium absorption or loss from the gut (see Regulation of calcium metabolism in the Calcium metabolism article).

### The blood partial pressure of oxygen and carbon dioxide homeostatsEdit

A cartoon of the effector mechanism employed by the blood gas homeostat. The partial pressures of the gases in the blood flowing through the mammalian lungs equilibrates with those in the approximately 3 liters of alveolar air that is always present in the lungs even after normal exhalation (indicated in the diagram by the light blue color in the sphere which represents the 3 liters of alveolar air). With each breath at rest, only about 350 ml of this alveolar air is replaced with ambient air (i.e. air from outside). This means that the composition of the alveolar air changes only minutely with each breath. Furthermore, the relatively long narrow tube separating the alveolar air from the ambient air allows the composition of the alveolar air to differ significantly from fresh atmospheric air: the oxygen concentration in the alveolar air is only about 60% of what it is in the atmosphere, while the carbon dioxide concentration, which is present only in trace quantities in the outside air, has a concentration of just over 5% in the alveoli. These alveolar concentrations of oxygen and carbon dioxide are kept constant by measuring the partial pressures of these gases in the blood that exits from the lungs (indicated in red on the right, in the diagram), in the aortic and carotid bodies, and adjusting the rate and depth of breathing accordingly. All the gas tensions are in kPa. To convert to mm Hg, multiply by 7.5.

The partial pressure of oxygen (${\displaystyle P_{{\mathrm {O} }_{2}}}$ ) in the arterial blood is measured in the aortic and carotid bodies, near the splitting of the common carotid artery into the internal and external carotid arteries. The partial pressure of carbon dioxide (${\displaystyle P_{{\mathrm {CO} }_{2}}}$ ) is measured on the surface of medulla oblongata of the brain. Information from these sets of sensors is sent to the respiratory center in the medulla oblongata of the brain which activates the effector organs, which, in this case, are the skeletal muscles of respiration (particularly the diaphragm). An increase in the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  of the blood, or a decrease in the ${\displaystyle P_{{\mathrm {O} }_{2}}}$ , causes deeper and more rapid breathing (hyperventilation) thus increasing the ventilation rate of the lung alveoli, which blows CO2 off, out of the blood, and into the outside air, while increasing the uptake of O2 from the alveolar air into the blood.

Too little CO2, and, to a lesser extent, too much O2, in the blood can temporarily halt breathing, which breath-holding divers use to prolong the time they can stay underwater.

The ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  homeostat is an important component of the pH of the extracellular fluid homeostat. At sea level it receives priority over the ${\displaystyle P_{{\mathrm {O} }_{2}}}$  homeostat. But above elevations of about 2500 m (or approximately 8000 ft) the rate of breathing is determined by the arterial ${\displaystyle P_{{\mathrm {O} }_{2}}}$  rather than the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ . (At 2500 m the atmospheric pressure and partial pressure of oxygen are 75% of what they are at sea level.) At higher elevations than this, the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  is allowed to fall, while hyperventilation now keeps the ${\displaystyle P_{{\mathrm {O} }_{2}}}$  constant. To keep the plasma pH at 7.4, despite the very low ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  levels as climbers ascend to these high elevations, the kidneys are stimulated secrete hydrogen ions (H+) into the blood while excreting of bicarbonate ions (HCO
3
) into the urine.[27][28] This is an important contribution to the acclimatization to high altitude.[29]

### The blood oxygen content homeostatEdit

The kidneys measure the oxygen content (rather than the ${\displaystyle P_{{\mathrm {O} }_{2}}}$ ) of the arterial blood. When the oxygen content of the blood is chronically low, these oxygen-sensitive cells secrete erythropoietin (EPO) into the blood. The effector tissue in this case is the red bone marrow which produces red blood cells (or erythrocytes). This tissue is stimulated by high levels of erythropoietin to increase the rate of red cell production, which leads to an increase in the hematocrit of the blood, and a consequent increase in its oxygen carrying capacity (due to the now high hemoglobin content of the blood). This is the mechanism whereby high altitude dwellers have higher hematocrits than sea-level residents, and also why persons with pulmonary insufficiency or right-to-left shunts in the heart (through which venous blood by-passes the lungs and goes directly into the systemic circulation) have similarly high hematocrits.[30][31]

The distinction between the ${\displaystyle P_{{\mathrm {O} }_{2}}}$  of the arterial blood and its oxygen content (or oxygen concentration) is important. The ${\displaystyle P_{{\mathrm {O} }_{2}}}$ is the pressure with which the oxygen has been forced into the blood in the alveoli of the lungs. The amount of oxygen that is consequently carried in the blood (at a given ${\displaystyle P_{{\mathrm {O} }_{2}}}$ ) depends on the hemoglobin concentration in the blood. The greater the hemoglobin concentration the greater the amount of oxygen that can be carried per liter of blood at that ${\displaystyle P_{{\mathrm {O} }_{2}}}$ . Thus, in anemia the ${\displaystyle P_{{\mathrm {O} }_{2}}}$  of the arterial blood is normal but the oxygen content is below normal. The oxygen content sensors in the kidneys detect this lower than normal oxygen concentration in the arterial blood, and increase their secretion of erythropoietin into the blood. This stimulates a greater rate of red blood cell production in the red bone marrow. This will correct the anemia, and therefore the oxygen concentration in the blood, if there are enough raw materials and co-factors (e.g. iron, vitamin B12 and folic acid) to manufacture the extra red cells.[30][32]

### The arterial blood pressure homeostatEdit

Stretch receptors in the walls of the aortic arch and carotid sinus (at the beginning of the internal carotid artery) act as arterial blood pressure sensors. As the pressure rises the arteries balloon out, stretching their walls. This information is then conveyed, via sensory nerves, to the medulla oblongata of the brain stem. From here motor nerves belonging to the autonomic nervous system are stimulated to influence the activity of chiefly the heart and the smallest diameter arteries, called arterioles. The arterioles are the main resistance vessels in the arterial tree, and small changes in diameter cause large changes in the resistance to flow through them. When the arterial blood pressure rises the arterioles are stimulated to dilate making it easier for blood to leave the arteries, thus deflating them, and bringing the blood pressure down, back to normal. At the same time the heart is stimulated via cholinergic parasympathetic nerves to beat more slowly (called bradycardia), ensuring that the inflow of blood into the arteries is reduced, thus adding to the reduction in pressure, and correction of the original error.

If the pressure in the arteries falls, the opposite reflex is elicited: constriction of the arterioles, and a speeding up of the heart rate (called tachycardia). If the drop in blood pressure is very rapid or excessive, the medulla oblongata stimulates the adrenal medulla, via "preganglionic" sympathetic nerves, to secrete epinephrine (adrenaline) into the blood. This hormone enhances the tachycardia and causes severe vasoconstriction of the arterioles to all but the essential organ in the body (especially the heart, lungs and brain). These reactions usually correct the low arterial blood pressure (hypotension) very effectively.

### The extracellular sodium concentration homeostatEdit

The sodium concentration homeostat is rather more complex than most of the other homeostats described on this page.

The sensor is situated in the juxtaglomerular apparatus of kidneys, which senses the plasma sodium concentration in a surprisingly indirect manner. Instead of measuring it directly in the blood flowing past the juxtaglomerular cells, these cells respond to the sodium concentration in the renal tubular fluid after it has already undergone a certain amount of modification in the proximal convoluted tubule and loop of Henle.[33] These cells also respond to rate of blood flow through the juxtaglomerular apparatus, which, under normal circumstances, is directly proportional to the arterial blood pressure, making this tissue an ancillary arterial blood pressure sensor.

In response to a lowering of the plasma sodium concentration, or to a fall in the arterial blood pressure, the juxtaglomerular cells release renin into the blood.[33][34][35] Renin is an enzyme which cleaves a decapeptide (a short protein chain, 10 amino acids long) from a plasma α-2-globulin called angiotensinogen. This decapeptide is known as angiotensin I.[33] It has no known biological activity. However, when the blood circulates through the lungs a pulmonary capillary endothelial enzyme called angiotensin-converting enzyme (ACE) cleaves a further two amino acids from angiotensin I to form an octapeptide known as angiotensin II. Angiotensin II is a hormone which acts on the adrenal cortex, causing the release into the blood of the steroid hormone, aldosterone. Angiotensin II also acts on the smooth muscle in the walls of the arterioles causing these small diameter vessels to constrict, thereby restricting the outflow of blood from the arterial tree, causing the arterial blood pressure to rise. This therefore reinforces the measures described above (under the heading of The arterial blood pressure homeostat), which defend the arterial blood pressure against changes, especially hypotension.

The angiotensin II-stimulated aldosterone released from the zona glomerulosa of the adrenal glands has an effect on particularly the epithelial cells of the distal convoluted tubules and collecting ducts of the kidneys. Here it causes the reabsorption of sodium ions from the renal tubular fluid, in exchange for potassium ions which are secreted from the blood plasma into the tubular fluid to exit the body via the urine.[33][36] The reabsorption of sodium ions from the renal tubular fluid halts further sodium ion losses from the body, and therefore preventing the worsening of hyponatremia. The hyponatremia can only be corrected by the consumption of salt in the diet. However, it is not certain whether a “salt hunger” can be initiated by hyponatremia, or by what mechanism this might come about.

When the plasma sodium ion concentration is higher than normal (hypernatremia), the release of renin from the juxtaglomerular apparatus is halted, ceasing the production of angiotensin II, and its consequent aldosterone-release into the blood. The kidneys respond by excreting sodium ions into the urine, thereby normalizing the plasma sodium ion concentration. The low angiotensin II levels in the blood lower the arterial blood pressure as an inevitable concomitant response.

The reabsorption of sodium ions from the tubular fluid as a result of high aldosterone levels in the blood does not, of itself, cause renal tubular water to be returned to the blood from the distal convoluted tubules or collecting ducts. This is because sodium is reabsorbed in exchange for potassium and therefore causes only a modest change in the osmotic gradient between the blood and the tubular fluid. Furthermore, the epithelium of the distal convoluted tubules and collecting ducts is impermeable to water in the absence of antidiuretic hormone (ADH) in the blood. ADH is part of the body water homeostat. Its levels in the blood vary with the osmolality of the plasma, which is measured in the hypothalamus of the brain. Aldosterone's action on the kidney tubules does not add sodium to the extracellular fluids (ECF) - it simply prevents further loss. So there is no change in the osmolality of the ECF, and therefore no change in the ADH concentration of the plasma. However, low aldosterone levels cause a loss of sodium ions from the ECF, which could potentially cause a change in extracellular osmolality and therefore of ADH levels in the blood.

### The extracellular potassium concentration homeostatEdit

The extracellular potassium ion (K+) concentration is sensed by the zona glomerulosa cells of the outer layer of the adrenal cortex, as well as, probably, by sensors in the carotid arteries.[37][38][39] High potassium concentrations in the plasma cause depolarization of the zona glomerulosa cells’ membranes.[37] This causes the release of aldosterone into the blood.

Aldosterone acts primarily on the distal convoluted tubules and collecting ducts of the kidneys, stimulating them to excrete potassium ions into the tubular fluid, and thus into the urine.[33] It does so, however, by activating the basolateral Na+/K+ pumps of the tubular epithelial cells. These sodium/potassium exchangers pump three sodium ions out of the cell, into the interstitial fluid and two potassium ions into the cell from the interstitial fluid. This creates concentration gradients which result in the reabsorption of sodium (Na+) ions from the tubular fluid into the blood, and secreting potassium (K+) ions from the blood into the urine (lumen of collecting duct).[40][41]

This obviously implies that excess potassium in the plasma can only be excreted at the expense of sodium retention by the body. The fact that the sodium and potassium homeostats seem to rely entirely on the same effector, but in opposite directions, implies that the body can only excrete potassium while retaining sodium, or vice versa. It cannot simultaneously excrete sodium and potassium ions in higher than modest quantities (when aldosterone is at an intermediate concentration in the plasma), and has no way of retaining both of them if there is a shortage in the body of the two cations. How these two conflicting homeostats (using the same effector) are disentangled to allow the plasma sodium and potassium ion levels to be regulated independently is currently not clear.

### The volume of body water homeostatEdit

The volume of water in the body is measured by stretch receptors in the heart atria, and, somewhat indirectly, by the measurement of the osmolality of the plasma by the hypothalamus. Measurement of the plasma osmolality to give an indication of the water content of the body, relies on the fact that water losses from the body, through sweat, gut fluids (normal fecal water losses, and through vomiting and diarrhea), and the exhaled air, are all hypotonic, meaning that they are less salty than the body fluids (compare, for instance, the taste of saliva with that of tears. The latter have almost the same salt content as the extracellular fluids, whereas the former is hypotonic with respect to plasma. Saliva does not taste salty, whereas tears are decidedly salty). Nearly all normal and abnormal losses of body water therefore cause the extracellular fluids to become hyperosmolar. Conversely excessive water intake (in the form of most regular beverages) dilutes the extracellular fluids causing the hypothalamus to register hypo-osmolar conditions.

When the hypothalamus detects a hyperosmolar extracellular environment, it causes the secretion from the posterior pituitary gland of a peptide hormone called antidiuretic hormone (ADH), which acts on the effector organ, which in this case is the kidney. The effect of ADH on the kidney tubules is to reabsorb water from the distal convoluted tubules and collecting ducts, thus preventing aggravation of the water loss via the urine. The hypothalamus simultaneously stimulates the nearby thirst center causing an almost irresistible (if the hyperosmolarity is severe enough) urge to drink water. The cessation of urine flow prevents the hypovolemia and hypertonicity from getting worse; the drinking of water corrects the defect.

Hypo-osmolality results in very low plasma ADH levels. This results in the inhibition of water reabsorption from the kidney tubules, causing high volumes of very dilute urine to be excreted, thus getting rid of the excess water in the body.

Note that urinary water loss, when the body water homeostat is intact, is a compensatory water loss, correcting any water excess in the body. However, since the kidneys cannot generate water, the thirst reflex is the all important second effector mechanism of the body water homeostat, correcting any water deficit in the body.

Stretching of the right atrium of the heart, usually a sign of an excessive blood volume, causes stretch receptors to secrete a hormone known as atrial natriuretic peptide (ANP) into the blood. This also acts on the kidneys causing sodium, and accompanying water loss into the urine, thereby reducing the volume of circulating blood.

### The extracellular fluid pH homeostatEdit

The pH of the extracellular fluids (which includes the blood plasma) is regulated by adjusting the ratio of the concentration of carbonic acid (H2CO3) to that of the bicarbonate ions (HCO
3
) to equal 1:20. This ratio and its relationship to the pH is described by the Henderson–Hasselbalch equation, which, when applied to the bicarbonate buffering system in the extracellular fluids, states that:[42]

${\displaystyle \mathrm {pH} =\mathrm {p} K_{\mathrm {a} ~\mathrm {H} _{2}\mathrm {CO} _{3}}+\log _{10}\left({\frac {[\mathrm {HCO} _{3}^{-}]}{[\mathrm {H} _{2}\mathrm {CO} _{3}]}}\right),}$

where:

However, since the carbonic acid concentration is directly proportional to the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  in the extracellular fluid, the Henderson–Hasselbalch equation can be rewritten as follows:[42]

${\displaystyle \mathrm {pH} =6.1+\log _{10}\left({\frac {[\mathrm {HCO} _{3}^{-}]}{0.0307\times P_{\mathrm {CO} _{2}}}}\right),}$

where:

• pH is the acidity in the plasma
• [HCO
3
]
is the concentration of bicarbonate in the plasma
• PCO2 is the partial pressure of carbon dioxide in the arterial blood plasma

There are therefore at least two homeostats responsible for the regulation of the plasma pH. The first is the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  homeostat described above which keeps the arterial blood ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  at 5.3 kPa (or 40 mm Hg). The sensor is on the surface of the medulla oblongata of the brain stem, which is also sensitive to the pH of the cerebrospinal fluid.[43] The effector organs are the muscles of respiration, which are stimulated via motor nerves to breathe faster and more deeply (hyperventilation) when the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  rises and the plasma pH falls, or more slowly and less deeply (hypoventilation) when the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  falls and the pH rises. Changes in the rate and depth of breathing can change the pH of the arterial plasma within a few seconds.

The sensor for the plasma HCO
3
concentration is not known for certain. It is very probable that the renal tubular cells of the distal convoluted tubules are themselves sensitive to the pH of the plasma. The metabolism of these cells produces CO2, which is rapidly converted to H+ and HCO
3
through the action of carbonic anhydrase.[24][43] When the extracellular fluids tend towards acidity, the renal tubular cells secrete the H+ ions into the tubular fluid from where they exit the body via the urine. The HCO
3
ions are simultaneously secreted into the blood plasma, thus raising the bicarbonate ion concentration in the plasma, increasing the [${\displaystyle \mathrm {HCO} _{3}^{-}]}$ :${\displaystyle P_{{\mathrm {CO} }_{2}}}$  ratio, and consequently the pH of the plasma.[43] The converse happens when the plasma pH rises above normal: bicarbonate ions are excreted into the urine, and hydrogen ions into the plasma.[nb 1]

## Homeostatic breakdownEdit

Many diseases are the result of the failure of one or more homeostat(s). Almost any functional component of any homeostat can malfunction, either as a result of an inherited defect, or an acquired disease. Some of the homeostats have inbuilt redundancies, which insures that life is not immediately threatened if a component malfunctions; but in other cases malfunction of a homeostat causes severe disease, which can be fatal if not treated. Here only a few well known examples of homeostat dysfunction are described.

Type 1 diabetes mellitus is probably the best known example. Here the blood glucose homeostat ceases to function because the beta cells of the pancreatic islets are destroyed. This means that the glucose sensor is absent, and its effector pathway (the insulin level in the blood) remains unchanged at zero. The blood glucose concentration therefore rises to very high levels, while the body’s proteins are degraded into amino acids which are turned at a very high rate into glucose, via gluconeogenesis, by the liver. The condition is fatal if not treated.

The plasma ionized calcium homeostat can be disrupted by the constant, unchanging, over-production of parathyroid hormone by a parathyroid adenoma resulting in the typically features of hyperparathyroidism, namely high plasma ionized Ca2+ levels and the resorption of bone, which can lead to spontaneous fractures. The abnormally high plasma ionized calcium concentrations cause conformational changes in many cell-surface proteins (especially ion channels and hormone or neurotransmitter receptors)[44] giving rise to lethargy, muscle weakness, anorexia, constipation and labile emotions.[45]

The body water homeostat can be compromised by the inability to secrete ADH in response to even the normal daily water losses via the exhaled air, the feces, and insensible sweating. On receiving a zero blood ADH signal, the kidneys produce huge unchanging volumes of very dilute urine, causing dehydration and death if not treated.

As organisms age, the efficiency of their control systems becomes reduced. The inefficiencies gradually result in an unstable internal environment that increases the risk of illness, and leads to the physical changes associated with aging.[6]

## Chronic disease compensation and decompensationEdit

Various chronic diseases are kept under control by homeostatic compensation, which masks a problem by compensating for it (making up for it) in another way. However, the compensating mechanisms eventually wear out or are disrupted by a new complicating factor (such as the advent of a concurrent acute viral infection), which sends the body reeling through a new cascade of events. Such decompensation unmasks the underlying disease, worsening its symptoms. Common examples include decompensated heart failure, kidney failure, and liver failure.

## Examples from technologyEdit

The following are all examples of familiar technological homeostatic mechanisms:

• A thermostat operates by switching heaters or air-conditioners on and off in response to the output of a temperature sensor.
• Cruise control adjusts a car's throttle in response to changes in speed.
• An autopilot operates the steering controls of an aircraft or ship in response to deviation from a pre-set compass bearing or route.
• Process control systems in a chemical plant or oil refinery maintain fluid levels, pressures, temperature, chemical composition, etc. by controlling heaters, pumps and valves.
• The centrifugal governor of a steam engine, as designed by James Watt in 1788, reduces the throttle valve in response to increases in the engine speed, or opens the valve if the speed falls below the pre-set rate.

## BiosphereEdit

In the Gaia hypothesis, James Lovelock[46] stated that the entire mass of living matter on Earth (or any planet with life) functions as a vast homeostatic superorganism that actively modifies its planetary environment to produce the environmental conditions necessary for its own survival. In this view, the entire planet maintains several homeostats (the primary one being temperature homeostasis). Whether this sort of system is present on Earth is open to debate. However, some relatively simple homeostatic mechanisms are generally accepted. For example, it is sometimes claimed that when atmospheric carbon dioxide levels rise, certain plants may be able to grow better and thus act to remove more carbon dioxide from the atmosphere. However, warming has exacerbated droughts, making water the actual limiting factor on land. When sunlight is plentiful and atmospheric temperature climbs, it has been claimed that the phytoplankton of the ocean surface waters, acting as global sunshine, and therefore heat sensors, may thrive and produce more dimethyl sulfide (DMS). The DMS molecules act as cloud condensation nuclei, which produce more clouds, and thus increase the atmospheric albedo, and this feeds back to lower the temperature of the atmosphere. However, rising sea temperature has stratified the oceans, separating warm, sunlit waters from cool, nutrient-rich waters. Thus, nutrients have become the limiting factor, and plankton levels have actually fallen over the past 50 years, not risen. As scientists discover more about Earth, vast numbers of positive and negative feedback loops are being discovered, that, together, maintain a metastable condition, sometimes within very broad range of environmental conditions.

## PredictiveEdit

Predictive homeostasis is an anticipatory response to an expected challenge in the future, such as the stimulation of insulin secretion by gut hormones which enter the blood in response to a meal.[23] This insulin secretion occurs before the blood sugar level rises, lowering the blood sugar level in anticipation of a large influx into the blood of glucose resulting from the digestion of carbohydrates in the gut. Such anticipatory reactions are open loop systems which are based, essentially, on “guess work”, and are not self-correcting.[47] Anticipatory responses always require a closed loop negative feedback system to correct the over- and undershoots to which the anticipatory systems are prone.

## Other fieldsEdit

The term has come to be used in other fields, for example:

### RiskEdit

Main article: Risk homeostasis

An actuary may refer to risk homeostasis, where (for example) people who have anti-lock brakes have no better safety record than those without anti-lock brakes, because the former unconsciously compensate for the safer vehicle via less-safe driving habits. Previous to the innovation of anti-lock brakes, certain maneuvers involved minor skids, evoking fear and avoidance: Now the anti-lock system moves the boundary for such feedback, and behavior patterns expand into the no-longer punitive area. It has also been suggested[citation needed] that ecological crises are an instance of risk homeostasis in which a particular behavior continues until proven dangerous or dramatic consequences actually occur.

### StressEdit

Sociologists and psychologists may refer to stress homeostasis, the tendency of a population or an individual to stay at a certain level of stress, often generating artificial stresses if the "natural" level of stress is not enough.[citation needed]

Jean-François Lyotard, a postmodern theorist, has applied this term to societal 'power centers' that he describes as being 'governed by a principle of homeostasis,' for example, the scientific hierarchy, which will sometimes ignore a radical new discovery for years because it destabilises previously accepted norms. (See The Postmodern Condition: A Report on Knowledge by Jean-François Lyotard)

## History of discoveryEdit

The conceptual origins of homeostasis reach back to Greek concepts such as balance, harmony, equilibrium, and steady-state; all believed to be fundamental attributes of life and health.[48] Thus, the philosopher Empedocles (495-435 BC) postulated that all matter consisted of elements and qualities that were in dynamic opposition or alliance to one another, and that balance or harmony was a necessary condition for the survival of living organisms. Following these hypotheses, Hippocrates (460-375 BC) compared health to the harmonious balance of the elements, and illness and disease to the systematic disharmony of these elements.[48][49]

Nearly 150 years ago, Claude Bernard published his seminal work, stating that the maintenance of the internal environment, or milieu intérieur, surrounding the body's cells, was essential for the life of the organism.[50] In 1929, Walter B. Cannon published an extrapolation from Bernard's 1865 work naming his theory "homeostasis".[48][50][51] Cannon postulated that homeostasis was a process of synchronized adjustments in the internal environment resulting in the maintenance of specific physiological variables within defined parameters; and that these precise parameters included blood pressure, temperature, pH, and others; all with clearly defined "normal" ranges. Cannon further posited that threats to homeostasis might originate from the external environment (e.g., temperature extremes, traumatic injury) or the internal environment (e.g., pain, infection), and could be physical or psychological, as in emotional distress.[50] Cannon's work outlined that maintenance of this internal physical and psychological balance, homeostasis, demands an internal network of communication, with sensors capable of identifying deviations from the acceptable ranges and effectors to return those deviations back within acceptable limits. Cannon identified these negative feedback systems and emphasized that, regardless of the nature of the threat to homeostasis, the response he mapped within the body would be the same.

## Etymology and pronunciationEdit

The word homeostasis (/ˌhmiˈstss/[52][53]) uses combining forms of homeo- and -stasis, New Latin from Greek: ὅμοιος homoios, "similar" and στάσις stasis, "standing still", yielding the idea of "staying the same".

## Foot noteEdit

1. ^ When H+ ions are excreted into the urine, and HCO
3
into the blood, the latter combine with the excess H+ ions in the plasma that stimulated the kidneys to perform this operation. The resulting reaction in the plasma [HCO
3
+ H+ = H2CO3] leads to the formation of carbonic acid, which is in equilibrium with the plasma ${\displaystyle P_{{\mathrm {CO} }_{2}}}$ . The latter is tightly regulated by the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  homeostat, ensuring that there is no build up (above normal) of carbonic acid or bicarbonate ions in the blood plasma. The overall effect is therefore that H+ ions are lost in the urine when the pH of the plasma falls. The concomitant rise in the plasma HCO
3
ion concentration mops up the excess of H+ ions in the plasma (which caused the fall in plasma pH). The resulting carbonic acid excess is then rapidly disposed of in the lungs as CO2, restoring the normal plasma [${\displaystyle \mathrm {HCO} _{3}^{-}]}$ :${\displaystyle P_{{\mathrm {CO} }_{2}}}$  ratio, and therefore the plasma pH. The converse happens when a high plasma pH stimulates the kidneys to excrete HCO
3
into the urine, and H+ ions into the blood. The H+ ions combine with the excess HCO
3
ions in the plasma, once again forming an excess of carbonic acid which can be blown off, as CO2, in the lungs, keeping the plasma bicarbonate ion concentration, the ${\displaystyle P_{{\mathrm {CO} }_{2}}}$  and, therefore, the plasma pH, constant.

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