Ramazzottius is a genus of water bear or moss piglet, a tardigrade in the class Eutardigrada.

Ramazzottius
Light micrographs of Ramazzottius varieornatus in its active state (A) and the cryptobiotic tun state (B)[1]
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Animalia
Phylum: Tardigrada
Class: Eutardigrada
Order: Parachela
Family: Hypsibiidae
Genus: Ramazzottius
Binda and Pilato, 1987
Species

see text

Ramazzottius varieornatus (see image) is a terrestrial invertebrate that is extroardinarily tolerant of extreme conditions such as irradiation, chemicals, dehydration and high pressure.[2] This tolerance is linked to the presence of the damage suppressor protein (Dsup) that binds to nucleosomes providing tolerance to DNA damage, such as that caused by ionizing radiation or hydroxyl radicals.[2][3]

Species edit

References edit

  1. ^ Neves, Ricardo Cardoso; Hvidepil, Lykke K. B.; Sørensen-Hygum, Thomas L.; Stuart, Robyn M.; Møbjerg, Nadja (9 January 2020). "Thermotolerance experiments on active and desiccated states of Ramazzottius varieornatus emphasize that tardigrades are sensitive to high temperatures". Scientific Reports. 10 (1): 94. Bibcode:2020NatSR..10...94N. doi:10.1038/s41598-019-56965-z. ISSN 2045-2322. PMC 6952461. PMID 31919388.
  2. ^ a b Ricci C, Riolo G, Marzocchi C, Brunetti J, Pini A, Cantara S. The Tardigrade Damage Suppressor Protein Modulates Transcription Factor and DNA Repair Genes in Human Cells Treated with Hydroxyl Radicals and UV-C. Biology (Basel). 2021 Sep 27;10(10):970. doi: 10.3390/biology10100970. PMID 34681069; PMCID: PMC8533384
  3. ^ Chavez C, Cruz-Becerra G, Fei J, Kassavetis GA, Kadonaga JT. The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals. Elife. 2019 Oct 1;8:e47682. doi: 10.7554/eLife.47682. PMID 31571581; PMCID: PMC6773438

External links edit