Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.[5][6][7]

RIN1
Identifiers
AliasesRIN1, Ras and Rab interactor 1
External IDsOMIM: 605965; MGI: 2385695; HomoloGene: 3170; GeneCards: RIN1; OMA:RIN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004292
NM_001363559
NM_001363560

NM_145495
NM_001374051
NM_001374052

RefSeq (protein)

NP_004283
NP_001350488
NP_001350489

NP_663470
NP_001360980
NP_001360981

Location (UCSC)Chr 11: 66.33 – 66.34 MbChr 19: 5.1 – 5.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

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RIN1 has been shown to interact with HRAS.[8][9]

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174791Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024883Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
  6. ^ Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
  7. ^ "Entrez Gene: RIN1 Ras and Rab interactor 1".
  8. ^ Mitin NY, Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21). United States: 22353–61. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
  9. ^ Han L, Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3). UNITED STATES: 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355. PMID 7862125.

Further reading

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