RIC3

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans. RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT₃ receptor and nicotinic acetylcholine receptors, particularly the homomeric α₇ nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.

RIC3
Identifiers
Aliases	RIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone, RIC-3
External IDs	OMIM: 610509; MGI: 2443887; HomoloGene: 49772; GeneCards: RIC3; OMA:RIC3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 8,106,056 bp End 8,169,055 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 108,633,519 bp End 108,682,538 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary left lobe of thyroid gland right lobe of thyroid gland right hemisphere of cerebellum body of pancreas right uterine tube left ovary gastric mucosa skin of abdomen minor salivary glands Top expressed in Rostral migratory stream dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex primary visual cortex lumbar subsegment of spinal cord superior frontal gyrus spermatocyte cerebellar cortex tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein folding chaperone activity acetylcholine receptor binding Cellular component integral component of membrane neuron projection Golgi membrane soma Golgi apparatus endoplasmic reticulum membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane Biological process positive regulation of cytosolic calcium ion concentration synaptic transmission, cholinergic protein localization to cell surface protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79608 320360 Ensembl ENSG00000166405 ENSMUSG00000048330 UniProt Q7Z5B4 Q8BPM6 RefSeq (mRNA) NM_001135109 NM_001206671 NM_001206672 NM_024557 NM_001346690 NM_001346691 NM_001346692 NM_001346693 NM_001346694 NM_001038624 NM_178780 NM_001311161 RefSeq (protein) NP_001128581 NP_001193600 NP_001193601 NP_001333619 NP_001333620 NP_001333621 NP_001333622 NP_001333623 NP_078833 NP_001033713 NP_001298090 NP_848895 Location (UCSC) Chr 11: 8.11 – 8.17 Mb Chr 7: 108.63 – 108.68 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Cheng A, Bollan KA, Greenwood SM, et al. (2007). "Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition". J. Biol. Chem. 282 (36): 26158–66. doi:10.1074/jbc.M703899200. PMID 17609200.
• Castillo M, Mulet J, Gutiérrez LM, et al. (2007). "Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Mol. Neurosci. 30 (1–2): 153–6. doi:10.1385/JMN:30:1:153. PMID 17192664. S2CID 41109579.
• Lansdell SJ, Gee VJ, Harkness PC, et al. (2005). "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells". Mol. Pharmacol. 68 (5): 1431–8. doi:10.1124/mol.105.017459. PMID 16120769. S2CID 12901942.
• Castillo M, Mulet J, Gutiérrez LM, et al. (2005). "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors". J. Biol. Chem. 280 (29): 27062–8. doi:10.1074/jbc.M503746200. hdl:10261/307538. PMID 15927954.
• Cheng A, McDonald NA, Connolly CN (2005). "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3". J. Biol. Chem. 280 (23): 22502–7. doi:10.1074/jbc.M414341200. PMID 15809299.
• Bennett HM, Lees K, et al. (2012). "Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes". J. Neurochem. 123 (6): 911–8. doi:10.1111/jnc.12013. PMC 3549563. PMID 22970690.
• Koperniak TM, Garg BK, et al. (2013). "Cell-specific effects on surface α7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein". J. Neurochem. 124 (3): 300–9. doi:10.1111/jnc.12095. PMID 23157401. S2CID 12489865.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.