RGS3

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.

RGS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F5Y, 2OJ4, 3FBK
Identifiers
Aliases	RGS3, C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3
External IDs	OMIM: 602189; MGI: 1354734; HomoloGene: 32440; GeneCards: RGS3; OMA:RGS3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q32 Start 113,444,731 bp End 113,597,743 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B3|4 33.19 cM Start 62,478,084 bp End 62,622,238 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart cartilage tissue periodontal fiber ascending aorta Descending thoracic aorta left ventricle gallbladder right auricle lateral nuclear group of thalamus granulocyte Top expressed in zygote granulocyte ventricular zone genital tubercle secondary oocyte external carotid artery internal carotid artery spermatid yolk sac neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component plasma membrane membrane nucleus nucleoplasm cytosol cytoplasm Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5998 50780 Ensembl ENSG00000138835 ENSMUSG00000059810 UniProt P49796 Q9DC04 RefSeq (mRNA) NM_001276260 NM_001276261 NM_001276262 NM_001282922 NM_001282923 NM_017790 NM_130795 NM_134427 NM_144488 NM_144489 NM_001322214 NM_001322215 NM_001351526 NM_001394167 NM_001081650 NM_019492 NM_134257 NM_001310706 RefSeq (protein) NP_001263189 NP_001263190 NP_001263191 NP_001269851 NP_001269852 NP_001309143 NP_001309144 NP_060260 NP_570613 NP_602299 NP_652759 NP_652760 NP_001338455 NP_001263189.1 NP_001269851.1 NP_001075119 NP_001297635 NP_062365 NP_599018 Location (UCSC) Chr 9: 113.44 – 113.6 Mb Chr 4: 62.48 – 62.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene". Genomics. 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dulin NO, Sorokin A, Reed E, Elliott S, Kehrl JH, Dunn MJ (1999). "RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11". Mol. Cell. Biol. 19 (1): 714–23. doi:10.1128/MCB.19.1.714. PMC 83928. PMID 9858594.
• Dulin NO, Pratt P, Tiruppathi C, Niu J, Voyno-Yasenetskaya T, Dunn MJ (2000). "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis". J. Biol. Chem. 275 (28): 21317–23. doi:10.1074/jbc.M910079199. PMID 10749886.
• Shi CS, Lee SB, Sinnarajah S, Dessauer CW, Rhee SG, Kehrl JH (2001). "Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation". J. Biol. Chem. 276 (26): 24293–300. doi:10.1074/jbc.M100089200. PMID 11294858.
• Lu Q, Sun EE, Klein RS, Flanagan JG (2001). "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction". Cell. 105 (1): 69–79. doi:10.1016/S0092-8674(01)00297-5. PMID 11301003. S2CID 12590781.
• Mittmann C, Schüler C, Chung CH, Not Available NA, Not Available NA, Not Available NA, Not Available NA (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart". Naunyn-Schmiedeberg's Arch. Pharmacol. 363 (4): 456–63. doi:10.1007/s002100000376. PMID 11330340. S2CID 36657400.
• Niu J, Scheschonka A, Druey KM, Davis A, Reed E, Kolenko V, Bodnar R, Voyno-Yasenetskaya T, Du X (2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain". Biochem. J. 365 (Pt 3): 677–84. doi:10.1042/BJ20020390. PMC 1222729. PMID 11985497.
• Kehrl JH, Srikumar D, Harrison K, Wilson GL, Shi CS (2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3". Genomics. 79 (6): 860–8. doi:10.1006/geno.2002.6773. PMID 12036301.
• Ikeda M, Okai M, Miyoshi T, Tone S, Minatogawa Y (2003). "Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha". Horm. Metab. Res. 34 (8): 425–30. doi:10.1055/s-2002-33599. PMID 12198596. S2CID 260167468.
• Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723. S2CID 45812827.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Tovey SC, Willars GB (2005). "Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor". Mol. Pharmacol. 66 (6): 1453–64. doi:10.1124/mol.104.005827. PMID 15383626. S2CID 24368533.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.