Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.[5][6][7]

RGS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS3, C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3
External IDsOMIM: 602189; MGI: 1354734; HomoloGene: 32440; GeneCards: RGS3; OMA:RGS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081650
NM_019492
NM_134257
NM_001310706

RefSeq (protein)

NP_001075119
NP_001297635
NP_062365
NP_599018

Location (UCSC)Chr 9: 113.44 – 113.6 MbChr 4: 62.48 – 62.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138835Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059810Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.
  6. ^ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339. S2CID 12703563.
  7. ^ a b "Entrez Gene: RGS3 regulator of G-protein signalling 3".

Further reading

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