- April 6, 1896 – The first international Olympic Games held in the modern era, the 1896 Summer Olympics (pictured), begin
- April 8, 2005 – The inaugural Islamic Solidarity Games open in Mecca, Saudi Arabia
- April 14, 1900 – Union Cycliste Internationale, the world governing body for sports cycling, is founded in Paris, France
- April 19, 1897 – The first Boston Marathon is run
- April 26, 2002 – The inaugural season of the China Baseball League begins