Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[5][6]

PKP3
Identifiers
AliasesPKP3, plakophilin 3
External IDsOMIM: 605561; MGI: 1891830; HomoloGene: 5200; GeneCards: PKP3; OMA:PKP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007183
NM_001303029

NM_001162924
NM_019762

RefSeq (protein)

NP_001289958
NP_009114

NP_001156396
NP_062736

Location (UCSC)Chr 11: 0.39 – 0.4 MbChr 7: 140.66 – 140.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[6]

Interactions

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PKP3 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184363Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054065Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
  6. ^ a b "Entrez Gene: PKP3 plakophilin 3".
  7. ^ a b c d Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. hdl:1854/LU-210987. PMC 2172904. PMID 12707304.

Further reading

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