Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase,[1][2][3][4][5] that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Identifiers
EC no.3.1.3.86
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2.

References

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  1. ^ Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR (May 1996). "p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity". Genes & Development. 10 (9): 1084–95. doi:10.1101/gad.10.9.1084. PMID 8654924.
  2. ^ Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G (February 1996). "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 93 (4): 1689–93. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691.
  3. ^ Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H (October 1997). "Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets". The Journal of Biological Chemistry. 272 (43): 26857–63. doi:10.1074/jbc.272.43.26857. PMID 9341117.
  4. ^ Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C (August 1996). "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase". Biochemical and Biophysical Research Communications. 225 (1): 243–9. doi:10.1006/bbrc.1996.1161. PMID 8769125.
  5. ^ Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C (October 1998). "The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity". FEBS Letters. 437 (3): 301–3. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312.
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