Phosphatidylcholine—retinol O-acyltransferase

In enzymology, a phosphatidylcholine---retinol O-acyltransferase (EC 2.3.1.135) is an enzyme that catalyzes the chemical reaction

phosphatidylcholine-retinol O-acyltransferase
Identifiers
EC no.2.3.1.135
CAS no.117444-03-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein]

Thus, the two substrates of this enzyme are phosphatidylcholine and [[retinol---[cellular-retinol-binding-protein]]], whereas its two products are 2-acylglycerophosphocholine and [[retinyl-ester---[cellular-retinol-binding-protein]]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase. Other names in common use include lecithin---retinol acyltransferase, phosphatidylcholine:retinol-(cellular-retinol-binding-protein), and O-acyltransferase.

References

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  • MacDonald PN, Ong DE (1988). "Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine". J. Biol. Chem. 263 (25): 12478–82. PMID 3410848.
  • Saari JC, Bredberg DL (1989). "Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes". J. Biol. Chem. 264 (15): 8636–40. PMID 2722792.