Perakine reductase (EC 1.1.1.317) is an enzyme with systematic name raucaffrinoline:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

Perakine reductase
Identifiers
EC no.1.1.1.317
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
raucaffrinoline + NADP+ perakine + NADPH + H+

The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway.

References

edit
  1. ^ Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stöckigt J (July 2008). "Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia". Plant Molecular Biology. 67 (5): 455–67. doi:10.1007/s11103-008-9331-7. PMID 18409028.
  2. ^ Rosenthal C, Mueller U, Panjikar S, Sun L, Ruppert M, Zhao Y, Stöckigt J (December 2006). "Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants". Acta Crystallographica Section F. 62 (Pt 12): 1286–9. doi:10.1107/S174430910605041X. PMC 2225361. PMID 17142919.
edit