Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.[5][6][7]

PRSS22
Identifiers
AliasesPRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDsOMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022119

NM_133731

RefSeq (protein)

NP_071402

NP_598492

Location (UCSC)Chr 16: 2.85 – 2.86 MbChr 17: 24.21 – 24.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.[5]

See also

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References

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  1. ^ a b c ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045027Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: protease".
  6. ^ Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi:10.1074/jbc.M108677200. PMID 11602603.
  7. ^ Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090. PMID 15701722.

Further reading

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