PRCP

This article is about the gene. For the postnominal, see Royal College of Physicians.

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.

PRCP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2Z
Identifiers
Aliases	PRCP, HUMPCP, PCP, prolylcarboxypeptidase
External IDs	OMIM: 176785 MGI: 1919711 HomoloGene: 55867 GeneCards: PRCP
Gene location (Human) Chr. Chromosome 11 (human) Band 11q14.1 Start 82,822,936 bp End 82,970,584 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 92,523,678 bp End 92,583,791 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node monocyte gallbladder periodontal fiber synovial joint left adrenal gland urethra smooth muscle tissue tibia human penis Top expressed in membranous bone maxilla dermis body of femur human mandible proximal tubule calvaria seminiferous tubule yolk sac spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine-type carboxypeptidase activity peptidase activity protein binding carboxypeptidase activity serine-type peptidase activity hydrolase activity dipeptidyl-peptidase activity Cellular component basal part of cell plasma membrane lysosome extracellular exosome azurophil granule membrane ficolin-1-rich granule membrane Biological process blood coagulation, intrinsic pathway glucose homeostasis regulation of reactive oxygen species metabolic process energy homeostasis plasma kallikrein-kinin cascade regulation of thyroid hormone mediated signaling pathway neutrophil degranulation negative regulation of systemic arterial blood pressure proteolysis regulation of blood vessel endothelial cell migration angiogenesis involved in wound healing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5547 72461 Ensembl ENSG00000137509 ENSMUSG00000061119 UniProt P42785 Q7TMR0 RefSeq (mRNA) NM_005040 NM_199418 NM_001319214 NM_028243 RefSeq (protein) NP_001306143 NP_005031 NP_955450 NP_082519 Location (UCSC) Chr 11: 82.82 – 82.97 Mb Chr 7: 92.52 – 92.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotensin II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

• Odya CE, Marinkovic DV, Hammon KJ, et al. (1978). "Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney". J. Biol. Chem. 253 (17): 5927–31. doi:10.1016/S0021-9258(17)34557-X. PMID 28321.
• Yang HY, Erdös EG, Chiang TS (1968). "New enzymatic route for the inactivation of angiotensin". Nature. 218 (5148): 1224–6. Bibcode:1968Natur.218.1224Y. doi:10.1038/2181224a0. PMID 4297812. S2CID 4245271.
• Jackman HL, Tan F, Schraufnagel D, et al. (1995). "Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages". Am. J. Respir. Cell Mol. Biol. 13 (2): 196–204. doi:10.1165/ajrcmb.13.2.7626287. PMID 7626287.
• Watson B, Nowak NJ, Myracle AD, et al. (1997). "The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension". Genomics. 44 (3): 365–7. doi:10.1006/geno.1997.4883. PMID 9325062.
• Shariat-Madar Z, Mahdi F, Schmaier AH (2002). "Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator". J. Biol. Chem. 277 (20): 17962–9. doi:10.1074/jbc.M106101200. PMID 11830581.
• Moreira CR, Schmaier AH, Mahdi F, et al. (2002). "Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator" (PDF). FEBS Lett. 523 (1–3): 167–70. doi:10.1016/S0014-5793(02)02980-0. hdl:2027.42/116370. PMID 12123826. S2CID 30374027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shariat-Madar Z, Mahdi F, Schmaier AH (2004). "Recombinant prolylcarboxypeptidase activates plasma prekallikrein" (PDF). Blood. 103 (12): 4554–61. doi:10.1182/blood-2003-07-2510. hdl:2027.42/106127. PMID 14996700. S2CID 339839.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Feng Y, Zhang Y, et al. (2006). "Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia". Am. J. Obstet. Gynecol. 195 (1): 162–71. doi:10.1016/j.ajog.2006.01.079. PMID 16681991.