PRB4

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.

PRB4
Identifiers
Aliases	PRB4, Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4
External IDs	OMIM: 180990 GeneCards: PRB4
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 11,307,077 bp End 11,310,436 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus bone marrow liver urinary bladder skin of abdomen blood lymph node lung islet of Langerhans spleen n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component extracellular region Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5545 n/a Ensembl ENSG00000274839 ENSG00000230657 n/a UniProt P10163 n/a RefSeq (mRNA) NM_002723 NM_001261399 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 11.31 – 11.31 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.

PRB4 is post-translationally cleaved into three different mature peptides:

• Protein N1
• Glycosylated protein A
• Peptide P-D (also known as proline-rich peptide IB-5)

Further reading

• Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–199. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
• Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
• Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. doi:10.1093/genetics/120.1.255. PMC 1203496. PMID 3220251.
• Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (inactive 31 January 2024). PMID 6377992.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
• Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
• Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi:10.1177/10454411930040030501. PMID 8373986.
• Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
• Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931. PMID 8554050.
• Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201. S2CID 42561185.