PLEKHF2

Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the PLEKHF2 gene.

PLEKHF2
Identifiers
Aliases	PLEKHF2, EAPF, PHAFIN2, ZFYVE18, pleckstrin homology and FYVE domain containing 2
External IDs	OMIM: 615208 MGI: 1919051 HomoloGene: 11620 GeneCards: PLEKHF2
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.1 Start 95,133,785 bp End 95,156,685 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A1 Start 10,988,662 bp End 11,007,927 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte palpebral conjunctiva bronchial epithelial cell monocyte sperm bone marrow corpus epididymis caput epididymis lymph node islet of Langerhans Top expressed in yolk sac spermatocyte morula proximal tubule endocardial cushion lip atrioventricular valve thymus esophagus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding phosphatidylinositol binding Cellular component endosome early endosome membrane transport vesicle endoplasmic reticulum membrane Biological process protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79666 71801 Ensembl ENSG00000175895 ENSMUSG00000049969 UniProt Q9H8W4 Q91WB4 RefSeq (mRNA) NM_024613 NM_175175 RefSeq (protein) NP_078889 NP_780384 Location (UCSC) Chr 8: 95.13 – 95.16 Mb Chr 4: 10.99 – 11.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.