PLA2G4C

Cytosolic phospholipase A₂ gamma is an enzyme that in humans is encoded by the PLA2G4C gene.

PLA2G4C
Identifiers
Aliases	PLA2G4C, CPLA2-gamma, phospholipase A2 group IVC
External IDs	OMIM: 603602; MGI: 1196403; HomoloGene: 115256; GeneCards: PLA2G4C; OMA:PLA2G4C - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 48,047,843 bp End 48,110,817 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A1|7 7.84 cM Start 13,058,580 bp End 13,094,597 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes inferior ganglion of vagus nerve muscle of thigh C1 segment vastus lateralis muscle corpus callosum right hemisphere of cerebellum apex of heart Skeletal muscle tissue of rectus abdominis triceps brachii muscle Top expressed in zygote secondary oocyte primary oocyte epithelium of stomach lumbar spinal ganglion Paneth cell morula parotid gland tail of embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase activity calcium-independent phospholipase A2 activity phospholipid binding hydrolase activity phospholipase A2 activity phospholipase A1 activity lysophospholipase activity calcium ion binding calcium-dependent phospholipid binding calcium-dependent phospholipase A2 activity Cellular component cytosol endoplasmic reticulum membrane membrane nuclear envelope nucleoplasm cell cortex cytoplasm Biological process intracellular signal transduction phosphatidylethanolamine acyl-chain remodeling glycerophospholipid catabolic process lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process birth phospholipid catabolic process phospholipid metabolic process metabolism inflammatory response arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8605 232889 Ensembl ENSG00000105499 ENSMUSG00000033847 UniProt Q9UP65 Q64GA5 RefSeq (mRNA) NM_001159322 NM_001159323 NM_003706 NM_001004762 NM_001168504 RefSeq (protein) NP_001152794 NP_001152795 NP_003697 NP_003697.2 NP_001004762 NP_001161976 Location (UCSC) Chr 19: 48.05 – 48.11 Mb Chr 7: 13.06 – 13.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Phospholipase A₂

Further reading

• Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Wu T, Angus CW, Yao XL, Logun C, Shelhamer JH (1997). "P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 272 (27): 17145–53. doi:10.1074/jbc.272.27.17145. PMID 9202034.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, Nguyen HT, Yaba P, Delicat A, Georges AJ, Russo-Marie F (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
• Hartmann C, Johnk L, Sasaki H, Jenkins RB, Louis DN (2002). "Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas". Brain Pathol. 12 (2): 178–82. doi:10.1111/j.1750-3639.2002.tb00432.x. PMC 8095768. PMID 11958371. S2CID 2579203.
• Stewart A, Ghosh M, Spencer DM, Leslie CC (2002). "Enzymatic properties of human cytosolic phospholipase A(2)gamma". J. Biol. Chem. 277 (33): 29526–36. doi:10.1074/jbc.M204856200. PMID 12039969.
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Asai K, Hirabayashi T, Houjou T, Uozumi N, Taguchi R, Shimizu T (2003). "Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress". J. Biol. Chem. 278 (10): 8809–14. doi:10.1074/jbc.M212117200. PMID 12502717.
• Jenkins CM, Han X, Yang J, Mancuso DJ, Sims HF, Muslin AJ, Gross RW (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry. 42 (40): 11798–807. doi:10.1021/bi034611q. PMID 14529291.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dong M, Johnson M, Rezaie A, Ilsley JN, Nakanishi M, Sanders MM, Forouhar F, Levine J, Montrose DC (2005). "Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis". Clin. Cancer Res. 11 (6): 2265–71. doi:10.1158/1078-0432.CCR-04-1079. PMID 15788676.
• Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW (2005). "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling". J. Biol. Chem. 280 (29): 26669–79. doi:10.1074/jbc.M502358200. PMID 15908428.
• Yamashita A, Kamata R, Kawagishi N, Nakanishi H, Suzuki H, Sugiura T, Waku K (2005). "Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)". J. Biochem. 137 (5): 557–67. doi:10.1093/jb/mvi067. PMID 15944408.
• Zhao X, Wang D, Zhao Z, Xiao Y, Sengupta S, Xiao Y, Zhang R, Lauber K, Wesselborg S (2006). "Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells". J. Biol. Chem. 281 (39): 29357–68. doi:10.1074/jbc.M513105200. PMID 16882668.