PHLPPL

PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is an enzyme which in humans is encoded by the PHLPPL gene.

PHLPP2
Identifiers
Aliases	PHLPP2, PHLPPL, PPM3B, PH domain and leucine rich repeat protein phosphatase 2
External IDs	OMIM: 611066 MGI: 2444928 HomoloGene: 71015 GeneCards: PHLPP2
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.2 Start 71,637,835 bp End 71,724,701 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 110,595,174 bp End 110,671,303 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa middle temporal gyrus retinal pigment epithelium germinal epithelium Brodmann area 46 duodenum postcentral gyrus superior frontal gyrus Brodmann area 23 rectum Top expressed in retinal pigment epithelium left colon dorsomedial hypothalamic nucleus jejunum hand ciliary body substantia nigra paraventricular nucleus of hypothalamus ventral tegmental area otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding protein binding protein serine/threonine phosphatase activity Cellular component cytoplasm cytosol membrane nucleus photoreceptor inner segment photoreceptor outer segment membrane Biological process hippocampus development protein dephosphorylation signal transduction negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23035 244650 Ensembl ENSG00000040199 ENSMUSG00000031732 UniProt Q6ZVD8 Q8BXA7 RefSeq (mRNA) NM_015020 NM_001289003 NM_001122594 RefSeq (protein) NP_001275932 NP_055835 NP_001116066 Location (UCSC) Chr 16: 71.64 – 71.72 Mb Chr 8: 110.6 – 110.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• PHLPP

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.
• Rizvi F, Shukla S, Kakkar P (2014). "Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity". Cell Death Dis. 5 (3): e1153. doi:10.1038/cddis.2014.118. PMC 3973230. PMID 24675471.