High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[5][6] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[7]

PDE8A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE8A, HsT19550, phosphodiesterase 8A
External IDsOMIM: 602972; MGI: 1277116; HomoloGene: 1957; GeneCards: PDE8A; OMA:PDE8A - orthologs
EC number3.1.4.53
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008803

RefSeq (protein)

NP_001230066
NP_002596
NP_775656

NP_032829

Location (UCSC)Chr 15: 84.98 – 85.14 MbChr 7: 80.86 – 80.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073417Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025584Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–577. doi:10.1006/bbrc.1998.8684. PMID 9618252.
  6. ^ "Entrez Gene: PDE8A phosphodiesterase 8A".
  7. ^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.

Further reading

edit