PCSK7

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.

PCSK7
Identifiers
Aliases	PCSK7, LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7
External IDs	OMIM: 604872 MGI: 107421 HomoloGene: 37955 GeneCards: PCSK7
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 117,204,337 bp End 117,232,525 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A5.2|9 25.32 cM Start 45,817,795 bp End 45,841,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa left uterine tube body of stomach lymph node rectum spleen blood stromal cell of endometrium anterior pituitary Top expressed in spermatocyte large intestine colon submandibular gland epithelium of stomach lip thymus left colon duodenum superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi apparatus membrane trans-Golgi network Biological process protein processing peptide hormone processing proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9159 18554 Ensembl ENSG00000160613 ENSMUSG00000035382 UniProt Q16549 Q61139 RefSeq (mRNA) NM_004716 NM_001281934 NM_008794 RefSeq (protein) NP_004707 NP_001268863 NP_032820 Location (UCSC) Chr 11: 117.2 – 117.23 Mb Chr 9: 45.82 – 45.84 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140.

This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.

References

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Further reading

• Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions". Biochimie. 76 (3–4): 197–209. doi:10.1016/0300-9084(94)90147-3. PMID 7819324.
• Moulard M, Decroly E (2001). "Maturation of HIV envelope glycoprotein precursors by cellular endoproteases". Biochim. Biophys. Acta. 1469 (3): 121–32. doi:10.1016/S0304-4157(00)00014-9. PMID 11063880.
• Tsuji A, Hine C, Mori K, et al. (1994). "A novel member, PC7, of the mammalian kexin-like protease family: homology to PACE4A, its brain-specific expression and identification of isoforms". Biochem. Biophys. Res. Commun. 202 (3): 1452–9. doi:10.1006/bbrc.1994.2094. PMID 8060327.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Meerabux J, Yaspo ML, Roebroek AJ, et al. (1996). "A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas". Cancer Res. 56 (3): 448–51. PMID 8564950.
• Decroly E, Wouters S, Di Bello C, et al. (1997). "Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines". J. Biol. Chem. 271 (48): 30442–50. doi:10.1074/jbc.271.48.30442. PMID 8940009.
• Hallenberger S, Moulard M, Sordel M, et al. (1997). "The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells". J. Virol. 71 (2): 1036–45. doi:10.1128/JVI.71.2.1036-1045.1997. PMC 191154. PMID 8995623.
• Decroly E, Benjannet S, Savaria D, Seidah NG (1997). "Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160". FEBS Lett. 405 (1): 68–72. doi:10.1016/S0014-5793(97)00156-7. PMID 9094426. S2CID 40785575.
• van de Loo JW, Creemers JW, Bright NA, et al. (1997). "Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase". J. Biol. Chem. 272 (43): 27116–23. doi:10.1074/jbc.272.43.27116. PMID 9341152.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Moulard M, Chaloin L, Canarelli S, et al. (1998). "Retroviral envelope glycoprotein processing: structural investigation of the cleavage site". Biochemistry. 37 (13): 4510–7. doi:10.1021/bi972662f. PMID 9521771.
• Mori K, Imamaki A, Nagata K, et al. (1999). "Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells". J. Biochem. 125 (3): 627–33. doi:10.1093/oxfordjournals.jbchem.a022329. PMID 10050053.
• Lecointe N, Meerabux J, Ebihara M, et al. (1999). "Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma". Oncogene. 18 (18): 2852–9. doi:10.1038/sj.onc.1202645. PMID 10362256.
• Wouters S, Decroly E, Vandenbranden M, et al. (1999). "Occurrence of an HIV-1 gp160 endoproteolytic activity in low-density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertases". FEBS Lett. 456 (1): 97–102. doi:10.1016/S0014-5793(99)00938-2. PMID 10452538. S2CID 7796014.
• Bhattacharjya S, Xu P, Zhong M, et al. (2000). "Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7". Biochemistry. 39 (11): 2868–77. doi:10.1021/bi9923961. PMID 10715106.
• Creemers JW, van de Loo JW, Plets E, et al. (2001). "Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation". J. Biol. Chem. 275 (49): 38842–7. doi:10.1074/jbc.M006758200. PMID 10964928.
• Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell. 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545. S2CID 18135412.