PARG

PARG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B1J, 5A7R, 4A0D, 4B1I, 4B1H, 4B1G
Identifiers
Aliases	PARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDs	OMIM: 603501; MGI: 1347094; HomoloGene: 50532; GeneCards: PARG; OMA:PARG - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	49,970,203 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	32,019,507 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; germinal epithelium; ; testicle; ; kidney tubule; ; ventricular zone; ; epithelium of nasopharynx; ; ganglionic eminence; ; corpus callosum; ; gingival epithelium; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	Gonadal ridge; ; primitive streak; ; stria vascularis; ; pineal gland; ; epiblast; ; ureter; ; morula; ; tail of embryo; ; morula; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; poly(ADP-ribose) glycohydrolase activity; protein binding;
Cellular component	mitochondrial matrix; intracellular membrane-bounded organelle; mitochondrion; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	ATP generation from poly-ADP-D-ribose; carbohydrate metabolic process; regulation of DNA repair; nucleotide-sugar metabolic process; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8505
	26430
	ENSG00000227345
	ENSMUSG00000021911
	Q86W56
	O88622
	NM_001303486; NM_001303487; NM_001303489; NM_003631; NM_001324381
	NM_011960; NM_001359915; NM_001374221
	NP_001290415; NP_001290416; NP_001290418; NP_001311310; NP_003622
	NP_036090; NP_001346844; NP_001361150
	Wikidata
View/Edit Human	View/Edit Mouse

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.^[5]^[6]^[7]

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000227345 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.
^ Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
^ Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. doi:10.1159/000015310. PMID 10449915. S2CID 42156664.

Affar, E. B.; Germain, M.; Winstall, E.; Vodenicharov, M.; Shah, R. G.; Salvesen, G. S.; Poirier, G. G. (2000). "Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis". Journal of Biological Chemistry. 276 (4): 2935–2942. doi:10.1074/jbc.M007269200. PMID 11053413.
Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochemical and Biophysical Research Communications. 307 (4): 915–921. doi:10.1016/S0006-291X(03)01272-5. PMID 12878198.
Meyer, R. G.; Meyer-Ficca, M. L.; Jacobson, E. L.; Jacobson, M. K. (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–190. doi:10.1016/S0378-1119(03)00738-8. PMID 14527731.
Golovanov, A. P.; Barillà, D.; Golovanova, M.; Hayes, F.; Lian, L. Y. (2003). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Molecular Microbiology. 50 (4): 1141–1153. doi:10.1046/j.1365-2958.2003.03750.x. PMID 14622405. S2CID 45704180.
Keil, C.; Petermann, E.; Oei, S. L. (2004). "Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts". Archives of Biochemistry and Biophysics. 425 (1): 115–121. doi:10.1016/j.abb.2004.02.024. PMID 15081900.
Meyer-Ficca, M. L.; Meyer, R. G.; Coyle, D. L.; Jacobson, E. L.; Jacobson, M. K. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Experimental Cell Research. 297 (2): 521–532. doi:10.1016/j.yexcr.2004.03.050. PMID 15212953.
Putt, K. S.; Hergenrother, P. J. (2004). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation". Analytical Biochemistry. 333 (2): 256–264. doi:10.1016/j.ab.2004.04.032. PMID 15450800.
Bonicalzi, M. -E.; Haince, J. -F.; Droit, A.; Poirier, G. G. (2005). "Poly-ADP-ribosylation in health and disease". Cellular and Molecular Life Sciences. 62 (7–8): 739–750. doi:10.1007/s00018-004-4505-1. PMID 15868399.
Bonicalzi, M. È.; Gagné, J. P.; Gagné, P.; Ouellet, M. È.; Hendzel, M. J.; Poirier, G. G. (2005). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". Biochemical Journal. 392 (3): 499–509. doi:10.1042/BJ20050792. PMC 1316289. PMID 16117724.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000227345 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.

[pmid9115250-6] Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. doi:10.1074/jbc.272.18.11895. PMID 9115250.

[pmid10449915-7] Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. doi:10.1159/000015310. PMID 10449915. S2CID 42156664.

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PARG

References

Further reading