Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.[5]

PANK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPANK1, PANK, pantothenate kinase 1
External IDsOMIM: 606160; MGI: 1922985; HomoloGene: 56979; GeneCards: PANK1; OMA:PANK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138316
NM_148977
NM_148978

NM_001114339
NM_023792

RefSeq (protein)

NP_612189
NP_683878
NP_683879

NP_001107811
NP_076281

Location (UCSC)Chr 10: 89.58 – 89.65 MbChr 19: 34.78 – 34.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2, PANK3, and PANK4. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152782Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033610Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PANK1 pantothenate kinase 1".

Further reading

edit