Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[5][6]

PAG1
Identifiers
AliasesPAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDsOMIM: 605767; MGI: 2443160; HomoloGene: 10198; GeneCards: PAG1; OMA:PAG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018440
NM_001007549

NM_001195031
NM_053182

RefSeq (protein)

NP_060910

NP_001181960
NP_444412

Location (UCSC)Chr 8: 80.97 – 81.11 MbChr 3: 9.75 – 9.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[6]

Interactions

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PAG1 has been shown to interact with FYN,[5] C-src tyrosine kinase,[5] Sodium-hydrogen antiporter 3 regulator 1[7] and Abl gene.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076641Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027508Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". The Journal of Experimental Medicine. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
  6. ^ a b "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
  7. ^ Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V (October 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085. S2CID 12676563.
  8. ^ Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.

Further reading

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