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Vascular organ of lamina terminalis

(Redirected from Organum vasculosum laminae terminalis)

The vascular organ of lamina terminalis (VOLT) (also known as organum vasculosum of the lamina terminalis (OVLT), or supraoptic crest[1]) Is a ependymal[2] chemosensory organ[3] of the third ventricle situated beneath the lamina terminalis. It overlies the paraventricular nucleus of hypothalamus.[2] The VOLT monitors the presence of peptides and macromolecules in the bloodstream, and conveys the information to the hypothalamus.[3]

Vascular organ of lamina terminalis
Details
Identifiers
Latinorganum vasculosum laminae terminalis
MeSHD066278
NeuroNames383
NeuroLex IDnlx_anat_100313
TA98A14.1.08.940
TA25781
FMA62315
Anatomical terms of neuroanatomy

It is one of the four sensory circumventricular organs of the brain (the others being the subfornical organ, the median eminence, and the area postrema).[4]

Anteroventral third ventricle region edit

The VOLT, median eminence, and subfornical organ are interconnected with the mid-ventral hypothalamus, and together these three structures surround the third ventricle, a complex often called the anteroventral region of the third ventricle ("AV3V" region).[4][5][6] This region functions in the regulation of fluid and electrolyte balance by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.[5][7]

Function edit

The VOLT is one of the four sensory circumventricular organs providing information to other brain regions (others are median eminence, subfornical organ, and area postrema).[4][8][9]

VOLT capillaries do not have a blood–brain barrier, and so neurons in this region can respond to circulating factors present in the systemic circulation.[4][7]

Neurons in the VOLT are osmoreceptors sensitive to the sodium content and osmotic pressure of blood.[5] Neurons of the lamina terminalis project to the supraoptic nucleus and paraventricular nucleus to regulate the activity of vasopressin-secreting neurons.[7] In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates receptors in the VOLT and subfornical organ to complete a positive feedback loop.[7][10][11] These neurons also project to the median preoptic nucleus which is involved in controlling thirst.[4][7][10]

References edit

  1. ^ "Organum vasculosum". BrainInfo, University of Washington, Seattle.
  2. ^ a b "organe vasculaire de la lame terminale l.m. - Dictionnaire médical de l'Académie de Médecine". www.academie-medecine.fr. Retrieved 2024-05-24.
  3. ^ a b Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. ISBN 978-1-118-67746-9.
  4. ^ a b c d e Gross, P. M; Weindl, A (1987). "Peering through the windows of the brain (review)". Journal of Cerebral Blood Flow & Metabolism. 7 (6): 663–72. doi:10.1038/jcbfm.1987.120. PMID 2891718. S2CID 18748366.
  5. ^ a b c Johnson, A. K (1985). "The periventricular anteroventral third ventricle (AV3V): Its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis". Brain Research Bulletin. 15 (6): 595–601. doi:10.1016/0361-9230(85)90209-6. PMID 3910170. S2CID 4781981.
  6. ^ Miyata, S (2015). "New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains". Frontiers in Neuroscience. 9: 390. doi:10.3389/fnins.2015.00390. PMC 4621430. PMID 26578857.
  7. ^ a b c d e Johnson, A. K; Gross, P. M (1993). "Sensory circumventricular organs and brain homeostatic pathways". FASEB Journal. 7 (8): 678–86. doi:10.1096/fasebj.7.8.8500693. PMID 8500693. S2CID 13339562.
  8. ^ Shaver, S. W; Pang, J. J; Wainman, D. S; Wall, K. M; Gross, P. M (1992). "Morphology and function of capillary networks in subregions of the rat tuber cinereum". Cell and Tissue Research. 267 (3): 437–48. doi:10.1007/bf00319366. PMID 1571958. S2CID 27789146.
  9. ^ Fry Mark, Ferguson Alastair V., (2007) The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior, Physiology & Behavior, Volume 91, Issue 4, 24 July 2007, Pages 413-423, ISSN 0031-9384, doi:10.1016/j.physbeh.2007.04.003.
  10. ^ a b McKinley, M. J; Allen, A. M; May, C. N; McAllen, R. M; Oldfield, B. J; Sly, D; Mendelsohn, F. A (2001). "Neural pathways from the lamina terminalis influencing cardiovascular and body fluid homeostasis". Clinical and Experimental Pharmacology and Physiology. 28 (12): 990–2. doi:10.1046/j.1440-1681.2001.03592.x. PMID 11903300. S2CID 43091000.
  11. ^ Fitzgerald, M J Turlough (2012). Clinical Neuroanatomy and Neuroscience. Philadelphia: Saunders Elsevier. p. 281. ISBN 978-0-7020-3738-2.


 

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