ORM1

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.

ORM1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3KQ0
Identifiers
Aliases	ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600 HomoloGene: 128040 GeneCards: ORM1
Gene location (Human) Chr. Chromosome 9 (human) Band 9q32 Start 114,323,098 bp End 114,326,479 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver bone marrow bone marrow cells blood trabecular bone right lung right adrenal gland upper lobe of left lung monocyte spleen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component blood microparticle extracellular exosome platelet alpha granule lumen extracellular space specific granule lumen tertiary granule lumen extracellular matrix extracellular region collagen-containing extracellular matrix Biological process negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of immune system process inflammatory response acute-phase response platelet degranulation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5004 n/a Ensembl ENSG00000229314 n/a UniProt P02763 n/a RefSeq (mRNA) NM_000607 n/a RefSeq (protein) NP_000598 n/a Location (UCSC) Chr 9: 114.32 – 114.33 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.

See also

• Orosomucoid

Further reading

• Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein". Biochem. J. 283 (1): 105–12. doi:10.1042/bj2830105. PMC 1131000. PMID 1567356.
• Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288. PMID 2409529.
• Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate". Prostate. 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939. S2CID 84445745.
• Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID 2541064. S2CID 42021177.
• Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein". EMBO J. 6 (8): 2289–96. doi:10.1002/j.1460-2075.1987.tb02503.x. PMC 553631. PMID 2822385.
• Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene". Gene. 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990.
• Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326.
• Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531. S2CID 34725840.
• Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA". Gene. 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479.
• Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040.
• Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment". Biochemistry. 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179.
• Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein". Biochemistry. 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214.
• Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins". Biochemistry. 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474.
• Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283. S2CID 13305518.
• Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416. S2CID 23508679.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis" (PDF). Inflammation. 17 (1): 33–45. doi:10.1007/BF00916390. hdl:2027.42/44509. PMID 8432561. S2CID 6012698.
• Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929. S2CID 21298011.
• Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum". Pharmacology. 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773.
• Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.