OR3A2

Olfactory receptor 3A2 is a protein that in humans is encoded by the OR3A2 gene.

OR3A2
Identifiers
Aliases	OR3A2, OLFRA04, OR17-14, OR17-228, OR228, olfactory receptor family 3 subfamily A member 2
External IDs	MGI: 3030244; HomoloGene: 68262; GeneCards: OR3A2; OMA:OR3A2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 3,276,942 bp End 3,386,317 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 74,221,107 bp End 74,228,857 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis islet of Langerhans ventricular zone nucleus accumbens sural nerve caudate nucleus granulocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process sensory perception of chemical stimulus sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4995 258702 Ensembl ENSG00000221882 ENSMUSG00000063116 UniProt P47893 Q8VFX7 RefSeq (mRNA) NM_002551 NM_146707 RefSeq (protein) NP_002542 NP_666918 Location (UCSC) Chr 17: 3.28 – 3.39 Mb Chr 11: 74.22 – 74.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
• Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome". Nat. Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR3A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.