Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene.[5][6][7]

OAZ1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOAZ1, AZI, OAZ, ornithine decarboxylase antizyme 1, AZ1
External IDsOMIM: 601579; MGI: 109433; HomoloGene: 7455; GeneCards: OAZ1; OMA:OAZ1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004152
NM_001301020

NM_001301034
NM_008753

RefSeq (protein)

NP_001287949
NP_004143

NP_001287963
NP_032779

Location (UCSC)Chr 19: 2.27 – 2.27 MbChr 10: 80.66 – 80.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104904Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035242Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tewari DS, Qian Y, Thornton RD, Pieringer J, Taub R, Mochan E, Tewari M (Feb 1995). "Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme". Biochim Biophys Acta. 1209 (2): 293–5. doi:10.1016/0167-4838(94)90199-6. PMID 7811704.
  6. ^ Matsufuji S, Inazawa J, Hayashi T, Miyazaki Y, Ichiba T, Furusaka A, Matsufuji T, Atkins JF, Gesteland RF, Murakami Y, Hayashi S (Mar 1997). "Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization". Genomics. 38 (1): 102–104. doi:10.1006/geno.1996.0601. PMID 8954789.
  7. ^ a b "Entrez Gene: OAZ1 ornithine decarboxylase antizyme 1".

Further reading

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