The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene.[5] NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.

NR4A3
Identifiers
AliasesNR4A3, CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3
External IDsOMIM: 600542; MGI: 1352457; HomoloGene: 5074; GeneCards: NR4A3; OMA:NR4A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006981
NM_173198
NM_173199
NM_173200

NM_015743
NM_001307989

RefSeq (protein)

NP_008912
NP_775291
NP_775292

NP_001294918
NP_056558

Location (UCSC)Chr 9: 99.82 – 99.87 MbChr 4: 48.05 – 48.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration,[6] metabolism[7][8] and apoptosis[9]

Interactions

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NR4A3 has been shown to interact with SIX3.[10][11]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119508Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028341Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hedvat CV, Irving SG (Dec 1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Molecular Endocrinology. 9 (12): 1692–700. doi:10.1210/mend.9.12.8614405. PMID 8614405.
  6. ^ Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (July 2016). "β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion". Am J Physiol Endocrinol Metab. 311 (1): E186–201. doi:10.1152/ajpendo.00022.2016. PMID 27221116.
  7. ^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (Nov 2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
  8. ^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (Jun 2008). "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.
  9. ^ Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (Nov 2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". The Journal of Biological Chemistry. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922.
  10. ^ Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (Jan 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Research. 63 (2): 449–54. PMID 12543801.
  11. ^ Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Developmental Neuroscience. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923. S2CID 84167063.

Further reading

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