The brewery was founded in 1840 by William Nicholson (1820–1916), son of successful businessman Robert Nicholson. The brewery was based in the centre of town with an extensive frontage on the High Street.
At their peak in the 1900s, Nicholson's possessed 150 tied pubs.
Nicholson's was bought out by Courage, Barclay & Simonds in 1958, and the site was closed three years later. It was demolished in 1962. The Nicholson's Centre shopping complex now stands on the site, covering the 400 ft deep artesian well that provided the brewery with its water.
- Helyer, Allison. "Local Historical Figures". www3.rbwm.gov.uk. Retrieved 9 June 2017.
- Richmond, Lesley; Turton, Alison (1990). The Brewing Industry: A Guide to Historical Records. Manchester University Press. p. 250. ISBN 9780719030321.
- Kupfermann, Elias; Dixon-Smith, Carol (5 November 2014). Maidenhead Through Time. Amberley Publishing Limited. p. 125. ISBN 9781445638539.