Neuropeptide Y receptor Y1

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.

NPY1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F1U, 2IIL
Identifiers
Aliases	NPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDs	OMIM: 162641; MGI: 104963; HomoloGene: 700; GeneCards: NPY1R; OMA:NPY1R - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.2 Start 163,323,962 bp End 163,344,832 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 B3.1|8 33.15 cM Start 67,149,844 bp End 67,159,444 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen popliteal artery tibial arteries right adrenal cortex left adrenal cortex Descending thoracic aorta adipose tissue germinal epithelium superficial temporal artery subcutaneous adipose tissue Top expressed in ascending aorta aortic valve dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex trigeminal ganglion muscle of thigh hippocampus proper posterior horn of spinal cord spinal ganglia More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity protein binding peptide YY receptor activity pancreatic polypeptide receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway locomotory behavior regulation of multicellular organism growth G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger outflow tract morphogenesis blood circulation regulation of blood pressure feeding behavior glucose metabolic process sensory perception of pain neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4886 18166 Ensembl ENSG00000164128 ENSMUSG00000036437 UniProt P25929 Q04573 RefSeq (mRNA) NM_000909 NM_010934 NM_001358955 RefSeq (protein) NP_000900 NP_035064 NP_001345884 Location (UCSC) Chr 4: 163.32 – 163.34 Mb Chr 8: 67.15 – 67.16 Mb PubMed search
Wikidata
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Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

Available Structures

• 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)
• 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)

See also

• Neuropeptide Y receptor

Further reading

• Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
• Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
• Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
• Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry. 267 (16): 10935–8. doi:10.1016/S0021-9258(19)49854-2. PMID 1317848.
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. Bibcode:1992PNAS...89.5794H. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
• Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
• Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
• Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622. S2CID 54419749.
• Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. S2CID 31244551.
• Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398. S2CID 41750584.
• Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. S2CID 40163065.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Körner M, Waser B, Reubi JC (December 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

External links

• "Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
• Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.