Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[5][6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

NPB
Identifiers
AliasesNPB, L7, PPL7, PPneuropeptide B
External IDsOMIM: 607996 MGI: 2387153 HomoloGene: 102151 GeneCards: NPB
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NPB
Genomic location for NPB
Band17q25.3Start81,900,745 bp[1]
End81,902,905 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_148896

NM_153288
NM_001347616
NM_001347617

RefSeq (protein)

NP_683694

NP_001334545
NP_001334546
NP_695020

Location (UCSC)Chr 17: 81.9 – 81.9 MbChr 11: 120.61 – 120.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
  6. ^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion". Results and problems in cell differentiation. 46: 239–56. doi:10.1007/400_2007_056. PMID 18204824.

External linksEdit