Nenad Ban is a Croatian biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology.

Nenad Ban
Nenad Ban (Scientist).jpg
Born (1966-05-03) May 3, 1966 (age 56)
NationalityCroatian
Alma materUniversity of Zagreb, Croatia, University of California at Riverside
Known forStructural biology, structure and function of the ribosome, structure and function of multi-enzymes
Spouse(s)Eilika Weber-Ban
AwardsNewcomb Cleveland Prize (2001)
Rössler Prize (2009)
Heinrich Wieland Prize (2010)
Ernst Jung Prize (2017)
Otto Naegeli Prize (2018)
Scientific career
FieldsBiochemistry and Biophysics
InstitutionsETH Zurich
Doctoral advisorAlexander McPherson
Other academic advisorsThomas A. Steitz

CareerEdit

Nenad Ban was born in 1966 in Zagreb. His parents, Jasna and Zvonimir, were scientists and university professors.[1] He received a degree in molecular biology at the Faculty of Science, University of Zagreb and decided to continue with his studies in the United States where he obtained a PhD degree at the University of California, Riverside in the laboratory of Alexander McPherson. His interest in large macromolecular assemblies led him for his postdoctoral work to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz. These results demonstrated that the ribosome is a ribozyme.[2]

Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich.[3] (Swiss Federal Institute of Technology). His group is studying structure and function of large cellular assemblies using a combination of crystallographic, electron microscopic and biochemical experiments. Specifically focusing on various ribosomal complexes[4][5] involved in co-translational protein processing,[6][7] folding,[8][9] and targeting.[10][6][11][8]

His group has obtained detailed structural information on eukaryotic ribosomes, which are significantly larger and more complex than their bacterial counterparts, by determining the first complete structures of both eukaryotic ribosomal subunits each in complex with an initiation factor.[12][13] Furthermore, his group investigated giant multifunctional enzymes involved in fatty acid synthesis offer first mechanistic insights into substrate shuttling and delivery in such megasynthases, with direct implications for our understanding of polyketide synthases.[14][15][16][17][18]

HonorsEdit

Nenad Ban is a member of the National Academy of Sciences, the European Molecular Biology Organization (EMBO), the German Academy of Sciences, the Croatian Academy of Arts and Sciences and the recipient of several prizes and awards including the Heinrich Wieland Prize,[19] Rössler Prize of the ETH Zurich,[20] the Latsis prize,[21] the Friedrich Miescher Prize of the Swiss Society for Biochemistry,[22] Spiridon Brusina medal, the AAAS Newcomb Cleveland Prize.[23] and the Ernst Jung Prize.[24]

Personal lifeEdit

Ban is married to Eilika Weber, a German scientist whom he met in the United States during his doctoral study. They have two sons, Arvid and Ivo.[1]

ReferencesEdit

  1. ^ a b Rudež, Tanja (26 February 2016). "Genijalnom Hrvatu za dlaku izmakla nobelova nagrada: Upoznajte čovjeka koji je riješio jedan od najvećih misterija molekularne biologije". Jutarnji list (in Croatian). Retrieved 26 February 2016.
  2. ^ Ban, Nenad; Nissen, Poul; Hansen, Jeffrey; Moore, Peter B.; Steitz, Thomas A. (11 August 2000). "The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 289 (5481): 905–920. Bibcode:2000Sci...289..905B. doi:10.1126/science.289.5481.905. ISSN 0036-8075. PMID 10937989.
  3. ^ "ETH Zurich: Prof. Nenad Ban". Mol.biol.ethz.ch. 2013-02-05. Archived from the original on 2013-09-10. Retrieved 2013-09-09.
  4. ^ Greber, Basil J; Boehringer, Daniel; Montellese, Christian; Ban, Nenad (11 November 2012). "Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit". Nature Structural & Molecular Biology. Springer Science and Business Media LLC. 19 (12): 1228–1233. doi:10.1038/nsmb.2425. ISSN 1545-9993. PMID 23142985. S2CID 36850669.
  5. ^ Greber, Basil J.; Boehringer, Daniel; Godinic-Mikulcic, Vlatka; Crnkovic, Ana; Ibba, Michael; Weygand-Durasevic, Ivana; Ban, Nenad (2012). "Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution". Journal of Molecular Biology. Elsevier BV. 418 (3–4): 145–160. doi:10.1016/j.jmb.2012.01.018. ISSN 0022-2836. PMC 3879142. PMID 22306461.
  6. ^ a b Estrozi, Leandro F; Boehringer, Daniel; Shan, Shu-ou; Ban, Nenad; Schaffitzel, Christiane (12 December 2010). "Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor". Nature Structural & Molecular Biology. Springer Science and Business Media LLC. 18 (1): 88–90. doi:10.1038/nsmb.1952. ISSN 1545-9993. PMC 3764645. PMID 21151118.
  7. ^ Bingel-Erlenmeyer, Rouven; Kohler, Rebecca; Kramer, Günter; Sandikci, Arzu; Antolić, Snježana; Maier, Timm; Schaffitzel, Christiane; Wiedmann, Brigitte; Bukau, Bernd; Ban, Nenad (20 February 2008). "A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing". Nature. Springer Science and Business Media LLC. 452 (7183): 108–111. Bibcode:2008Natur.452..108B. doi:10.1038/nature06683. ISSN 0028-0836. PMID 18288106. S2CID 4411842.
  8. ^ a b Ferbitz, Lars; Maier, Timm; Patzelt, Holger; Bukau, Bernd; Deuerling, Elke; Ban, Nenad (29 August 2004). "Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins". Nature. Springer Science and Business Media LLC. 431 (7008): 590–596. Bibcode:2004Natur.431..590F. doi:10.1038/nature02899. ISSN 0028-0836. PMID 15334087. S2CID 4427021.
  9. ^ Kramer, Günter; Rauch, Thomas; Rist, Wolfgang; Vorderwülbecke, Sonja; Patzelt, Holger; Schulze-Specking, Agnes; Ban, Nenad; Deuerling, Elke; Bukau, Bernd (2002). "L23 protein functions as a chaperone docking site on the ribosome". Nature. Springer Science and Business Media LLC. 419 (6903): 171–174. Bibcode:2002Natur.419..171K. doi:10.1038/nature01047. ISSN 0028-0836. PMID 12226666. S2CID 2365591.
  10. ^ Ataide, Sandro F.; Schmitz, Nikolaus; Shen, Kuang; Ke, Ailong; Shan, Shu-ou; Doudna, Jennifer A.; Ban, Nenad (18 February 2011). "The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor". Science. American Association for the Advancement of Science (AAAS). 331 (6019): 881–886. Bibcode:2011Sci...331..881A. doi:10.1126/science.1196473. ISSN 0036-8075. PMC 3758919. PMID 21330537.
  11. ^ Schaffitzel, Christiane; Oswald, Miro; Berger, Imre; Ishikawa, Takashi; Abrahams, Jan Pieter; Koerten, Henk K.; Koning, Roman I.; Ban, Nenad (29 October 2006). "Structure of the E. coli signal recognition particle bound to a translating ribosome". Nature. Springer Science and Business Media LLC. 444 (7118): 503–506. Bibcode:2006Natur.444..503S. doi:10.1038/nature05182. ISSN 0028-0836. PMID 17086205. S2CID 4400092.
  12. ^ Klinge, Sebastian; Voigts-Hoffmann, Felix; Leibundgut, Marc; Arpagaus, Sofia; Ban, Nenad (18 November 2011). "Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6". Science. American Association for the Advancement of Science (AAAS). 334 (6058): 941–948. Bibcode:2011Sci...334..941K. doi:10.1126/science.1211204. ISSN 0036-8075. PMID 22052974. S2CID 206536444.
  13. ^ Rabl, Julius; Leibundgut, Marc; Ataide, Sandro F.; Haag, Andrea; Ban, Nenad (11 February 2011). "Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1". Science. American Association for the Advancement of Science (AAAS). 331 (6018): 730–736. Bibcode:2011Sci...331..730R. doi:10.1126/science.1198308. hdl:20.500.11850/153130. ISSN 0036-8075. PMID 21205638. S2CID 24771575.
  14. ^ Maier, Timm; Leibundgut, Marc; Ban, Nenad (5 September 2008). "The Crystal Structure of a Mammalian Fatty Acid Synthase". Science. American Association for the Advancement of Science (AAAS). 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. ISSN 0036-8075. PMID 18772430. S2CID 3168991.
  15. ^ Leibundgut, Marc; Jenni, Simon; Frick, Christian; Ban, Nenad (13 April 2007). "Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase". Science. American Association for the Advancement of Science (AAAS). 316 (5822): 288–290. Bibcode:2007Sci...316..288L. doi:10.1126/science.1138249. ISSN 0036-8075. PMID 17431182. S2CID 32176226.
  16. ^ Jenni, Simon; Leibundgut, Marc; Boehringer, Daniel; Frick, Christian; Mikolásek, Bohdan; Ban, Nenad (13 April 2007). "Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling". Science. American Association for the Advancement of Science (AAAS). 316 (5822): 254–261. Bibcode:2007Sci...316..254J. doi:10.1126/science.1138248. ISSN 0036-8075. PMID 17431175. S2CID 12820568.
  17. ^ Maier, Timm; Jenni, Simon; Ban, Nenad (3 March 2006). "Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 311 (5765): 1258–1262. Bibcode:2006Sci...311.1258M. doi:10.1126/science.1123248. ISSN 0036-8075. PMID 16513975. S2CID 39658597.
  18. ^ Jenni, Simon; Leibundgut, Marc; Maier, Timm; Ban, Nenad (3 March 2006). "Architecture of a Fungal Fatty Acid Synthase at 5 Å Resolution". Science. American Association for the Advancement of Science (AAAS). 311 (5765): 1263–1267. Bibcode:2006Sci...311.1263J. doi:10.1126/science.1123251. ISSN 0036-8075. PMID 16513976. S2CID 2191407.
  19. ^ "Heinrich Wieland Prize". Heinrich-wieland-preis.de. 2010-10-28. Archived from the original on 2013-06-30. Retrieved 2013-09-09.
  20. ^ "ETH Zürich – Archiv 2009". Ethz.ch. Retrieved 2013-09-09.
  21. ^ "Preistragende des Latsis-Preises". ETH Zürich (in German). 30 November 2020. Retrieved 27 November 2021.
  22. ^ scnat.ch. "Awardees". Swissbiochem.ch. Archived from the original on 2013-10-29. Retrieved 2013-09-09.
  23. ^ "Newcomb Cleveland Prize – Recipients". AAAS. Archived from the original on 2012-10-23. Retrieved 2013-09-09.
  24. ^ "Professor Tobias Moser and Professor Nenad Ban". jung-stiftung.de. Retrieved 2017-01-09.

External linksEdit