National Shrine of Saint Joseph may refer to:
- Santuário Nacional de São José de Anchieta (Santuário Nacional do São José de Anchieta), Anchieta, Espírito Santo, Brazil
- Saint Joseph's Oratory (Oratoire Saint-Joseph du Mont-Royal), Montréal, Québec, Canada
- National Shrine of Saint Joseph (Karlovac) (Nacionalno Svetište sv. Josipa), Karlovac, Croatia
- National Shrine of Saint Joseph (Mandaue), Cebu, Philippines
- National Shrine of Saint Joseph (De Pere, Wisconsin), USA
- Cathedral of San José de Mayo, Uruguay