Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene.[5][6] It belongs to the Nudix family of hydrolases.

NUDT21
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT21, CFIM25, CPSF5, nudix hydrolase 21
External IDsOMIM: 604978; MGI: 1915469; HomoloGene: 5090; GeneCards: NUDT21; OMA:NUDT21 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007006

NM_026623

RefSeq (protein)

NP_008937

NP_080899

Location (UCSC)Chr 16: 56.43 – 56.45 MbChr 8: 94.74 – 94.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.[7] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167005Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031754Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
  6. ^ a b "Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21".
  7. ^ Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

Further reading

edit