Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] is an enzyme that in humans is encoded by the NUDT2 gene.[5][6][7]

NUDT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT2, APAH1, nudix hydrolase 2, IDDPN
External IDsOMIM: 602852; MGI: 1913651; HomoloGene: 896; GeneCards: NUDT2; OMA:NUDT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_147173
NM_001161
NM_001244390
NM_147172

NM_025539

RefSeq (protein)

NP_001152
NP_001231319
NP_671701
NP_671702

NP_079815

Location (UCSC)Chr 9: 34.33 – 34.34 MbChr 4: 41.47 – 41.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164978Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028443Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thorne NM, Hankin S, Wilkinson MC, Nunez C, Barraclough R, McLennan AG (Dec 1995). "Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases". Biochem J. 311 (3): 717–21. doi:10.1042/bj3110717. PMC 1136061. PMID 7487923.
  6. ^ McLennan AG, Flannery AV, Morten JE, Ridanpaa M (Apr 1998). "Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13". Genomics. 47 (2): 307–9. doi:10.1006/geno.1997.5092. PMID 9479504.
  7. ^ a b "Entrez Gene: NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2".

Further reading

edit