NUB1

NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene.

NUB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJU
Identifiers
Aliases	NUB1, BS4, NUB1L, NYREN18, negative regulator of ubiquitin-like proteins 1, negative regulator of ubiquitin like proteins 1
External IDs	OMIM: 607981 MGI: 1889001 HomoloGene: 41108 GeneCards: NUB1
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 151,341,772 bp End 151,378,449 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 24,890,530 bp End 24,915,376 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibia monocyte visceral pleura appendix parietal pleura islet of Langerhans rectum lymph node right uterine tube Top expressed in morula seminiferous tubule superior frontal gyrus spermatid cerebellar cortex entorhinal cortex paraventricular nucleus of hypothalamus thymus medulla oblongata lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus cytosol nucleolus Biological process response to tumor necrosis factor response to interferon-gamma positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51667 53312 Ensembl ENSG00000013374 ENSMUSG00000028954 UniProt Q9Y5A7 P54729 RefSeq (mRNA) NM_001243351 NM_016118 NM_001363529 NM_001385353 NM_001385354 NM_001385355 NM_001385356 NM_001385361 NM_016736 NM_001305264 RefSeq (protein) NP_001230280 NP_057202 NP_001350458 NP_001292193 NP_058016 Location (UCSC) Chr 7: 151.34 – 151.38 Mb Chr 5: 24.89 – 24.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM]

Interactions

NUB1 has been shown to interact with NEDD8, UBD and AIPL1.

Further reading

• Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (Dec 2001). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1". The Journal of Biological Chemistry. 276 (49): 46655–60. doi:10.1074/jbc.M108636200. PMID 11585840.
• Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM (Oct 2002). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Human Molecular Genetics. 11 (22): 2723–33. doi:10.1093/hmg/11.22.2723. PMC 2585502. PMID 12374762.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC (May 2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Tanaka T, Kawashima H, Yeh ET, Kamitani T (Aug 2003). "Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L". The Journal of Biological Chemistry. 278 (35): 32905–13. doi:10.1074/jbc.M212057200. PMID 12816948.
• Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• van der Spuy J, Kim JH, Yu YS, Szel A, Luthert PJ, Clark BJ, Cheetham ME (Dec 2003). "The expression of the Leber congenital amaurosis protein AIPL1 coincides with rod and cone photoreceptor development". Investigative Ophthalmology & Visual Science. 44 (12): 5396–403. doi:10.1167/iovs.03-0686. PMID 14638743.
• Hipp MS, Raasi S, Groettrup M, Schmidtke G (Apr 2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". The Journal of Biological Chemistry. 279 (16): 16503–10. doi:10.1074/jbc.M310114200. PMID 14757770.
• Tanaka T, Yeh ET, Kamitani T (Mar 2004). "NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis". European Journal of Biochemistry. 271 (5): 972–82. doi:10.1111/j.1432-1033.2004.03999.x. PMID 15009209.
• Kanaya K, Sohocki MM, Kamitani T (May 2004). "Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis". Biochemical and Biophysical Research Communications. 317 (3): 768–73. doi:10.1016/j.bbrc.2004.03.108. PMID 15081406.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• van der Spuy J, Cheetham ME (Nov 2004). "The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments". The Journal of Biological Chemistry. 279 (46): 48038–47. doi:10.1074/jbc.M407871200. PMID 15347646.
• Schmidtke G, Kalveram B, Weber E, Bochtler P, Lukasiak S, Hipp MS, Groettrup M (Jul 2006). "The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10". The Journal of Biological Chemistry. 281 (29): 20045–54. doi:10.1074/jbc.M603063200. PMID 16707496.
• Tanji K, Tanaka T, Mori F, Kito K, Takahashi H, Wakabayashi K, Kamitani T (Aug 2006). "NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1". The American Journal of Pathology. 169 (2): 553–65. doi:10.2353/ajpath.2006.051067. PMC 1698792. PMID 16877356.