NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene .[ 3] [ 4] [ 5]
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV ) domain (PYD), followed by a NACHT domain , a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR ) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1 ) via their involvement in multiprotein complexes called inflammasomes .[ 5]
^ a b c ENSG00000167634, ENSG00000278173, ENSG00000277179, ENSG00000274174, ENSG00000277776, ENSG00000277786, ENSG00000275483, ENSG00000277071, ENSG00000274571 GRCh38: Ensembl release 89: ENSG00000276804, ENSG00000167634, ENSG00000278173, ENSG00000277179, ENSG00000274174, ENSG00000277776, ENSG00000277786, ENSG00000275483, ENSG00000277071, ENSG00000274571 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol . 4 (2): 95–104. doi :10.1038/nrm1019 . PMID 12563287 . S2CID 31417018 . ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing" . J Biol Chem . 277 (33): 29874–80. doi :10.1074/jbc.M203915200 PMID 12019269 . ^ a b "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7" .
Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol . 3 (5): 371–82. doi :10.1038/nri1086 . PMID 12766759 . S2CID 8088987 . Moglabey YB, Kircheisen R, Seoud M, et al. (1999). "Genetic mapping of a maternal locus responsible for familial hydatidiform moles" . Hum. Mol. Genet . 8 (4): 667–71. doi :10.1093/hmg/8.4.667 PMID 10072436 . Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett . 530 (1–3): 73–8. doi :10.1016/S0014-5793(02)03416-6 . PMID 12387869 . S2CID 25023390 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Okada K, Hirota E, Mizutani Y, et al. (2005). "Oncogenic role of NALP7 in testicular seminomas" . Cancer Sci . 95 (12): 949–54. doi :10.1111/j.1349-7006.2004.tb03182.x PMC 11158205 PMID 15596043 . S2CID 13403889 . Kinoshita T, Wang Y, Hasegawa M, et al. (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion" . J. Biol. Chem . 280 (23): 21720–5. doi :10.1074/jbc.M410057200 hdl :2297/2649 PMID 15817483 . Murdoch S, Djuric U, Mazhar B, et al. (2006). "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans". Nat. Genet . 38 (3): 300–2. doi :10.1038/ng1740 . PMID 16462743 . S2CID 28580007 . Bestor TH, Bourc'his D (2006). "Genetics and epigenetics of hydatidiform moles". Nat. Genet . 38 (3): 274–6. doi :10.1038/ng0306-274 . PMID 16501554 . S2CID 22981053 . Djuric U, El-Maarri O, Lamb B, et al. (2007). "Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation" . Hum. Genet . 120 (3): 390–5. doi :10.1007/s00439-006-0192-3 . PMID 16874523 . S2CID 10117000 . Qian J, Deveault C, Bagga R, et al. (2007). "Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations" . Hum. Mutat . 28 (7): 741. doi :10.1002/humu.9498 PMID 17579354 . S2CID 43136262 .
