NET1

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.

NET1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EO2, 4XH9
Identifiers
Aliases	NET1, ARHGEF8, NET1A, neuroepithelial cell transforming 1
External IDs	OMIM: 606450 MGI: 1927138 HomoloGene: 4283 GeneCards: NET1
Gene location (Human) Chr. Chromosome 10 (human) Band 10p15.1 Start 5,412,557 bp End 5,459,056 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 3,932,018 bp End 3,968,220 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva pericardium pylorus cardia urethra superior surface of tongue trigeminal ganglion parotid gland rectum inferior ganglion of vagus nerve Top expressed in lip intestinal villus esophagus yolk sac duodenum maxillary prominence ankle ascending aorta left lung lobe colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding Cellular component cytoplasm cytosol plasma membrane nucleus intracellular anatomical structure Biological process cellular response to ionizing radiation positive regulation of GTPase activity myoblast migration positive regulation of substrate adhesion-dependent cell spreading regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction regulation of cell growth signal transduction cellular response to hydrogen peroxide positive regulation of apoptotic process G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10276 56349 Ensembl ENSG00000173848 ENSMUSG00000021215 UniProt Q7Z628 Q5SQI7 Q9Z206 RefSeq (mRNA) NM_001047160 NM_005863 NM_001047159 NM_019671 RefSeq (protein) NP_001040625 NP_005854 NP_005854.2 NP_001040624 NP_062645 Location (UCSC) Chr 10: 5.41 – 5.46 Mb Chr 13: 3.93 – 3.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Shen X, Li J, Hu PP, et al. (2001). "The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation". J. Biol. Chem. 276 (18): 15362–8. doi:10.1074/jbc.M009534200. PMID 11278519.
• Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin H, Carr HS, Wu X, et al. (2005). "Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1". J. Biol. Chem. 280 (9): 7603–13. doi:10.1074/jbc.M412141200. PMID 15611121.
• Alberts AS, Qin H, Carr HS, Frost JA (2005). "PAK1 negatively regulates the activity of the Rho exchange factor NET1". J. Biol. Chem. 280 (13): 12152–61. doi:10.1074/jbc.M405073200. PMID 15684429.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Leyden J, Murray D, Moss A, et al. (2006). "Net1 and Myeov: computationally identified mediators of gastric cancer". Br. J. Cancer. 94 (8): 1204–12. doi:10.1038/sj.bjc.6603054. PMC 2361249. PMID 16552434.
• García-Mata R, Dubash AD, Sharek L, et al. (2007). "The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity". Mol. Cell. Biol. 27 (24): 8683–97. doi:10.1128/MCB.00157-07. PMC 2169424. PMID 17938206.

External links

• NET1 human gene location in the UCSC Genome Browser.
• NET1 human gene details in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Neuroepithelial cell-transforming gene 1 protein (NET1)