Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[5][6]

NBR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDsOMIM: 166945; MGI: 108498; HomoloGene: 7438; GeneCards: NBR1; OMA:NBR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291571
NM_001291572
NM_005899
NM_031858
NM_031862

NM_001252220
NM_001252222
NM_001252223
NM_008676

RefSeq (protein)

NP_001278500
NP_001278501
NP_005890
NP_114068

NP_001239149
NP_001239151
NP_001239152
NP_032702

Location (UCSC)Chr 17: 43.17 – 43.21 MbChr 11: 101.44 – 101.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[7]

Interactions

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NBR1 has been shown to interact with FEZ1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188554Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017119Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
  6. ^ a b "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
  7. ^ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.
  8. ^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading

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