N-sulfoglucosamine-3-sulfatase

The enzyme N-sulfoglucosamine-3-sulfatase (EC 3.1.6.15}) catalyzes cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.[1][2]

N-sulfoglucosamine-3-sulfatase
Identifiers
EC no.3.1.6.15
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic nameis N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradation of glycan structures.

References

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  1. ^ Bruce JS, McLean MW, Long WF, Williamson FB (1985). "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148 (2): 359–65. doi:10.1111/j.1432-1033.1985.tb08847.x. PMID 3987694.
  2. ^ Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94 (4): 1183–9. doi:10.1016/0006-291X(80)90544-6. PMID 7396957.