Murid gammaherpesvirus 4 (MuHV-4) is a species of virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae. This species infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.[1] Murid gammaherpesvirus 4 currently serves as a model for study of human gammaherpesvirus pathogenesis.[2]
| Murid gammaherpesvirus 4 | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Peploviricota |
| Class: | Herviviricetes |
| Order: | Herpesvirales |
| Family: | Orthoherpesviridae |
| Genus: | Rhadinovirus |
| Species: | Murid gammaherpesvirus 4
|
Strains
editSeven strains of Murid gammaherpesvirus 4 have been isolated, including the following six:
- MuHV-Šum
- MuHV-60
- MuHV-68
- MuHV-72
- MuHV-76
- MuHV-4556
References
edit
Wikimedia Commons has media related to Murid herpesvirus 4.
Wikispecies has information related to Murid gammaherpesvirus 4.
- ^ Jela Mistríková & Július Rajčáni (2008). "Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome". Central European Journal of Biology. 3 (1 / March, 2008). doi:10.2478/s11535-008-0002-0.
- ^ Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M (2006). "Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains". Virus Genes. 33 (1): 51–8. doi:10.1007/s11262-005-0038-4. PMID 16791419. S2CID 25195454.