Motile sperm domain containing 3

Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene.

MOSPD3
Identifiers
Aliases	MOSPD3, CDS3, NET30, Motile sperm domain containing 3
External IDs	OMIM: 609125 MGI: 1916179 HomoloGene: 11406 GeneCards: MOSPD3
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,612,102 bp End 100,615,384 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G2|5 76.59 cM Start 137,594,907 bp End 137,599,320 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence sperm right lobe of liver skin of abdomen nipple amygdala canal of the cervix trachea cerebellar vermis body of tongue Top expressed in yolk sac lip esophagus neural tube superior cervical ganglion secondary oocyte thymus interventricular septum superior frontal gyrus visual cortex More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 64598 68929 Ensembl ENSG00000106330 ENSMUSG00000037221 UniProt O75425 Q8BGG6 RefSeq (mRNA) NM_001040097 NM_001040098 NM_001040099 NM_023948 NM_001363415 NM_001363416 NM_001254762 NM_030037 RefSeq (protein) NP_001035186 NP_001035187 NP_001035188 NP_076438 NP_001350344 NP_001350345 NP_001241691 NP_084313 Location (UCSC) Chr 7: 100.61 – 100.62 Mb Chr 5: 137.59 – 137.6 Mb PubMed search
Wikidata
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Function

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.

Further reading

• Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (October 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Research. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
• Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM (December 2004). "A novel transmembrane MSP-containing protein that plays a role in right ventricle development". Genomics. 84 (6): 1051–9. doi:10.1016/j.ygeno.2004.08.017. PMID 15533722.
• Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AW, Akkermans JJ, Wijdeven RH, Janssen GM, van Veelen PA, Neefjes J (December 2020). "Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10): 108475. doi:10.1016/j.celrep.2020.108475. hdl:1887/3184381. PMID 33296653. S2CID 228090430.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.