Motile sperm domain containing 2

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene. It is an endoplasmic reticulum–resident protein involved in membrane contact site formation. Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

MOSPD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIC
Identifiers
Aliases	MOSPD2, Motile sperm domain containing 2
External IDs	MGI: 1924013 HomoloGene: 22125 GeneCards: MOSPD2
Gene location (Human) Chr. X chromosome (human) Band Xp22.2 Start 14,873,421 bp End 14,922,327 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F5 Start 163,719,165 bp End 163,763,371 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte corpus callosum inferior ganglion of vagus nerve monocyte subthalamic nucleus visceral pleura blood pons superior vestibular nucleus ventral tegmental area Top expressed in parotid gland carotid body ciliary body sciatic nerve iris left lung lobe conjunctival fornix seminal vesicula calvaria submandibular gland More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 158747 76763 Ensembl ENSG00000130150 ENSMUSG00000061778 UniProt Q8NHP6 Q9CWP6 RefSeq (mRNA) NM_001177475 NM_152581 NM_001330241 NM_001290523 NM_001290524 NM_029730 RefSeq (protein) NP_001170946 NP_001317170 NP_689794 NP_001277452 NP_001277453 NP_084006 Location (UCSC) Chr X: 14.87 – 14.92 Mb Chr X: 163.72 – 163.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E, Edwards TL (March 2013). "Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study". Human Genetics. 132 (3): 323–36. doi:10.1007/s00439-012-1246-3. PMC 3704217. PMID 23192594.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain-containing protein 2