Mopeia mammarenavirus (MOPV) is a species of virus in the genus Mammarenavirus.[1] It was initially isolated from the Mastomys natalensis mouse in the East African country of Mozambique in 1977.[2][3][4] It is of the "Old World" Arenavirus lineage and is closely related to Lassa mammarenavirus, sharing 75% of its amino acid sequence.[5][6]
| Mopeia mammarenavirus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Ellioviricetes |
| Order: | Bunyavirales |
| Family: | Arenaviridae |
| Genus: | Mammarenavirus |
| Species: | Mopeia mammarenavirus
|
| Strains | |
| |
| Synonyms | |
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Mopeia virus, MOPV, Mozambique virus, MV | |
Mopeia virus disease edit
Mopeia virus has not been known to cause disease in humans, although it is capable of infecting human cell lines in vitro.[7] Infection of primates with the virus was demonstrated to prevent clinical disease following Lassa virus infection, indicating potential for use as a prophylactic vaccine for Lassa Fever.[8]
Geographic distribution edit
Although initially isolated in Mozambique, it has also been detected in rodents in Zimbabwe,[9] and Tanzania.[4] Although not identified outside of these regions, it is possible that M. natalensis rodents could carry Mopeia virus to other areas of Southeast Africa.[citation needed]
References edit
- ^ "Genus: Mammarenavirus - Arenaviridae - Negative-sense RNA Viruses - ICTV". talk.ictvonline.org. Retrieved 8 May 2022.[dead link]
- ^ Wulff H, McIntosh BM, Hamner DB, Johnson KM (1977). "Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Africa". Bulletin of the World Health Organization. 55 (4): 441–444. PMC 2366678. PMID 304387.
- ^ Grobbelaar AA, Jardine J, Burt FJ, Shepherd AJ, Shepherd SP, Leman PA, et al. (December 2021). "Mammarenaviruses of Rodents, South Africa and Zimbabwe". Emerging Infectious Diseases. 27 (12): 3092–3102. doi:10.3201/eid2712.211088. PMC 8632164. PMID 34808083.
- ^ a b Borremans B, Leirs H, Gryseels S, Günther S, Makundi R, de Bellocq JG (August 2011). "Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission". Vector Borne and Zoonotic Diseases. 11 (8): 1125–1131. doi:10.1089/vbz.2010.0010. PMID 21142956.
- ^ Gonzalez JP, Emonet S, de Lamballerie X, Charrel R (2007). Childs JE, Mackenzie JS, Richt JA (eds.). "Arenaviruses". Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission. Current Topics in Microbiology and Immunology. 315. Berlin, Heidelberg: Springer Berlin Heidelberg: 253–88. doi:10.1007/978-3-540-70962-6_11. ISBN 978-3-540-70961-9. PMC 7122678. PMID 17848068.
- ^ Pannetier D, Faure C, Georges-Courbot MC, Deubel V, Baize S (October 2004). "Human macrophages, but not dendritic cells, are activated and produce alpha/beta interferons in response to Mopeia virus infection". Journal of Virology. 78 (19): 10516–10524. doi:10.1128/JVI.78.19.10516-10524.2004. PMC 516411. PMID 15367618.
- ^ Borremans B, Leirs H, Gryseels S, Günther S, Makundi R, de Bellocq JG (August 2011). "Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission". Vector Borne and Zoonotic Diseases. 11 (8): 1125–1131. doi:10.1089/vbz.2010.0010. PMID 21142956.
- ^ Kiley MP, Lange JV, Johnson KM (October 1979). "Protection of rhesus monkeys from Lassa virus by immunisation with closely related Arenavirus". Lancet. 2 (8145): 738. doi:10.1016/s0140-6736(79)90659-7. PMID 90819. S2CID 37185713.
- ^ Johnson KM, Taylor P, Elliott LH, Tomori O (November 1981). "Recovery of a Lassa-related arenavirus in Zimbabwe". The American Journal of Tropical Medicine and Hygiene. 30 (6): 1291–1293. doi:10.4269/ajtmh.1981.30.1291. PMID 7034562.