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Monoblasts are bipotent cells that differentiated from hematopoietic stem cells. They are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.

Monoblast
Monoblast.png
Monoblast
Details
SystemImmune system
LocationBone marrow
FunctionA precursor monocyte
Identifiers
THH2.00.04.3.08002
Anatomical terms of microanatomy

Contents

StructureEdit

A typical monoblast is about 12 to 20 µm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure. One to four nucleoli are usually visible. The nucleus can be central or eccentric and it can show evidence of indentation or folding. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone.

DevelopmentEdit

The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte -> monocyte-> macrophage.

Additional imagesEdit

See alsoEdit