Mitochondrial ribosomal protein L37

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.

MRPL37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p32.3 Start 54,184,041 bp End 54,225,464 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C7 Start 106,913,071 bp End 106,924,065 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh right adrenal gland skin of arm right adrenal cortex tibialis anterior muscle left ventricle right lobe of liver left adrenal gland apex of heart Top expressed in genital tubercle tail of embryo muscle of thigh right kidney ventricular zone embryo lip skeletal muscle tissue embryo triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51253 56280 Ensembl ENSG00000116221 ENSMUSG00000028622 UniProt Q9BZE1 Q921S7 RefSeq (mRNA) NM_016491 NM_001330602 NM_025500 RefSeq (protein) NP_001317531 NP_057575 NP_079776 Location (UCSC) Chr 1: 54.18 – 54.23 Mb Chr 4: 106.91 – 106.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Levshenkova EV, Ukraintsev KE, Orlova VV, et al. (2005). "[The structure and specific features of the cDNA expression of the human gene MRPL37]". Bioorg. Khim. 30 (5): 499–506. doi:10.1023/b:rubi.0000043788.86955.ea. PMID 15562971. S2CID 342310.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BZE1 (39S ribosomal protein L37, mitochondrial) at the PDBe-KB.