In molecular biology mir-320 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-320 | |
|---|---|
 Conserved secondary structure of mir-320 | |
| Identifiers | |
| Symbol | mir-320 |
| Rfam | RF00736 |
| miRBase family | MIPF0000163 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
The biogenesis of miR-320 is different from the canonical Microprocessor-dependent miRNAs. The pre-miR-320 is transcribed directly as a precursor microRNA hairpin and thus contains a 5′ m7G-cap.
See also
editReferences
edit- ^ Xia HF, Jin XH, Song PP, Cui Y, Liu CM, Ma X (2010). "Temporal and spatial regulation of miR-320 in the uterus during embryo implantation in the rat". Int J Mol Sci. 11 (2): 719–730. doi:10.3390/ijms11020719. PMC 2852863. PMID 20386663.
- ^ Duan H, Jiang Y, Zhang H, Wu Y (2010). "MiR-320 and miR-494 affect cell cycles of primary murine bronchial epithelial cells exposed to benzo[a]pyrene". Toxicol in Vitro. 24 (3): 928–935. doi:10.1016/j.tiv.2009.11.013. PMID 19925859.
- ^ Ling HY, Ou HS, Feng SD, Zhang XY, Tuo QH, Chen LX, Zhu BY, Gao ZP, Tang CK, Yin WD, Zhang L, Liao DF (2009). "Changes in microRNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes". Clin Exp Pharmacol Physiol. 36 (9): e32–e39. doi:10.1111/j.1440-1681.2009.05207.x. PMID 19473196. S2CID 10568446.
- ^ Ren XP, Wu J, Wang X, Sartor MA, Qian J, Jones K, Nicolaou P, Pritchard TJ, Fan GC (2009). "MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20". Circulation. 119 (17): 2357–2366. doi:10.1161/CIRCULATIONAHA.108.814145. PMC 2746735. PMID 19380620.
- ^ Schaar DG, Medina DJ, Moore DF, Strair RK, Ting Y (2009). "miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation". Exp Hematol. 37 (2): 245–255. doi:10.1016/j.exphem.2008.10.002. PMID 19135902.
- ^ Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM (2009). "MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats". Clin Exp Pharmacol Physiol. 36 (2): 181–188. doi:10.1111/j.1440-1681.2008.05057.x. PMID 18986336. S2CID 205458045.
- ^ Ling, HY; Ou, HS; Feng, SD; Zhang, XY; Tuo, QH; Chen, LX; Zhu, BY; Gao, ZP; Tang, CK; Yin, WD; Zhang, L; Liao, DF (September 2009). "CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes". Clinical and Experimental Pharmacology & Physiology. 36 (9): e32–9. doi:10.1111/j.1440-1681.2009.05207.x. PMID 19473196. S2CID 10568446.
- ^ Xie, M; Li, M; Vilborg, A; Lee, N; Yartseva, V; Sestan, N; Steitz, J (September 2013). "Mammalian 5′-Capped MicroRNA Precursors that Generate a Single MicroRNA". Cell. 155 (7): 1568–1580. doi:10.1016/j.cell.2013.11.027. PMC 3899828. PMID 24360278.
External links
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