MI-2 or Mi-2 can refer to:
- Michigan's 2nd congressional district
- Mil Mi-2, a light helicopter
- Mission: Impossible 2, a 2000 action spy film
- Anti-Mi-2 antibodies
- Mi-2 complex, also known as NuRD (nucleosome remodeling deacetylase) complex
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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