Methandriol bisenanthoyl acetate

Methandriol bisenanthoyl acetate (brand name Notandron-Depot), or methylandrostenediol bisenanthoyl acetate, also known as 17α-methylandrost-5-ene-3β,17β-diol 3β,17β-di(3-oxononanoate), is a synthetic, injected anabolic–androgenic steroid (AAS) and a 17α-alkylated derivative of 5-androstenediol.[1][2] It is an androgen ester—specifically, the C3β,17β di(3-oxononanoate) (or dienanthoylacetate) ester of methandriol (17α-methyl-5-androstenediol)—and acts as a prodrug of methandriol in the body.[1] Methandriol bisenanthoyl acetate is administered by intramuscular injection and, relative to methandriol, has an extended duration via this route due to a depot effect afforded by its ester.[citation needed]

Methandriol bisenanthoyl acetate
Methandriol bisenanthoyl acetate.svg
Clinical data
Trade namesNotandron-Depot
Other namesMethandriol dioxononanoate; Methylandrostenediol dioxononanoate; Methandriol bisoxononanoate; Methylandrostenediol bisoxononanoate; 17α-Methylandrost-5-ene-3,17β-diol 3,17β-di(3-oxononanoate)
Routes of
Intramuscular injection
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass612.892 g·mol−1
3D model (JSmol)

See alsoEdit


  1. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 663–. ISBN 978-3-88763-075-1.
  2. ^ Rogozkin VA (14 June 1991). Metabolism of Anabolic-Androgenic Steroids. CRC Press. pp. 15–. ISBN 978-0-8493-6415-0.